{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:56:55Z","timestamp":1761659815852,"version":"build-2065373602"},"reference-count":6,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A 63\u2010year\u2010old man was administered pembrolizumab for stage IV squamous cell lung cancer. After 54\u2009cycles of pembrolizumab, the patient maintained complete remission of lung cancer but developed nasal obstruction, olfactory disturbance, conjunctivitis, stomatitis, glossitis, pharyngitis, and weight loss. Laboratory data showed increased levels of neutrophils, eosinophils, C\u2010reactive protein, squamous cell carcinoma antigen, and cytokeratin 19 fragments. Sinus computed tomography revealed obstruction of the maxillary, ethmoid, and sphenoidal sinuses. Histological examination of nasal septal tissue revealed chronic rhinosinusitis with infiltration primarily of eosinophils, neutrophils, CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes, and CD20\n                    <jats:sup>+<\/jats:sup>\n                    B lymphocytes, along with destruction of nasal epithelium and glands. The patient was diagnosed with immune\u2010related chronic rhinosinusitis and treated with oral prednisolone after discontinuation of pembrolizumab. Herein, we report a rare case of pembrolizumab\u2010induced chronic rhinosinusitis without nasal polyps that was successfully treated with oral corticosteroid therapy.\n                  <\/jats:p>","DOI":"10.1002\/rcr2.70362","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T02:14:57Z","timestamp":1759716897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pembrolizumab\u2010Induced Chronic Rhinosinusitis in a Patient With Non\u2010Small Cell Lung Cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4533-4164","authenticated-orcid":false,"given":"Yuji","family":"Yamasaki","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine and Allergology Kochi Medical School, Kochi University  Nankoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Allergology Kochi Medical School, Kochi University  Nankoku Japan"},{"name":"Department of Integrative Respiratory Medicine Ehime University Graduate School of Medicine  Toon Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Komori","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Kochi Medical School, Kochi University  Nankoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Allergology Kochi Medical School, Kochi University  Nankoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuko","family":"Iguchi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Kochi Medical School Kochi University  Nankoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Allergology Kochi Medical School, Kochi University  Nankoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23213"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894241273192"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.638"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12644"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606774"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2017.06.016"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:53:47Z","timestamp":1761659627000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":6,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/rcr2.70362"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70362","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70362"}}