{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:36:18Z","timestamp":1791466578083,"version":"4.3.4"},"reference-count":5,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Connective tissue disease (CTD)\u2013associated interstitial lung disease (ILD) accounts for a significant proportion of ILD cases, with rheumatoid arthritis (RA) being one of the most common underlying disorders. Although immunosuppressive therapy plays a central role in CTD\u2010ILD, its efficacy is limited in fibrotic ILDs, particularly those with a usual interstitial pneumonia (UIP) pattern. We report a case of RA\u2010associated ILD in an elderly woman who experienced acute disease progression despite ongoing treatment. A multimodal approach combining corticosteroids, tacrolimus, antifibrotic therapy (nintedanib) and the Janus kinase (JAK) inhibitor baricitinib led to marked clinical, radiological and biomarker improvement. This case underscores the potential benefit of a multi\u2010target strategy addressing both inflammation and fibrosis and suggests a possible role for JAK inhibition in refractory RA\u2010ILD.<\/jats:p>","DOI":"10.1002\/rcr2.70378","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T01:35:42Z","timestamp":1762133742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rheumatoid Arthritis\u2010Associated Interstitial Pneumonia Refractory to Initial Therapy: Successful Control Through Combined Anti\u2010Inflammatory, Antifibrotic and\n                    <scp>JAK<\/scp>\n                    \u2010\n                    <scp>STAT<\/scp>\n                    \u2010Targeted Treatment"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3716-1898","authenticated-orcid":false,"given":"Takao","family":"Kodera","sequence":"first","affiliation":[{"name":"Division of Hematology and Rheumatology Tohoku Medical and Pharmaceutical University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Oka","sequence":"additional","affiliation":[{"name":"Division of Hematology and Rheumatology Tohoku Medical and Pharmaceutical University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Shirota","sequence":"additional","affiliation":[{"name":"Division of Hematology and Rheumatology Tohoku Medical and Pharmaceutical University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Kubota","sequence":"additional","affiliation":[{"name":"Division of Hematology and Rheumatology Tohoku Medical and Pharmaceutical University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Soeda","sequence":"additional","affiliation":[{"name":"Division of Hematology and Rheumatology Tohoku Medical and Pharmaceutical University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Kameoka","sequence":"additional","affiliation":[{"name":"Division of Hematology and Rheumatology Tohoku Medical and Pharmaceutical University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Ishii","sequence":"additional","affiliation":[{"name":"Division of Hematology and Rheumatology Tohoku Medical and Pharmaceutical University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00869-2018"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40904"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmx118"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010024\u201005695\u20101"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2017.12.016"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T04:38:07Z","timestamp":1764131887000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":5,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/rcr2.70378"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70378","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70378"}}