{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T19:11:16Z","timestamp":1769541076770,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Immunoglobulin G4\u2010related disease (IgG4\u2010RD) is a fibroinflammatory condition that can involve multiple organs, including mediastinal lesions. Transbronchial mediastinal cryobiopsy has recently emerged as a novel sampling technique that improves diagnostic yield for mediastinal lesions, particularly in rare tumours and benign disorders, compared to endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA). Here we report a case of IgG4\u2010RD presenting with hilar and mediastinal lymphadenopathy successfully diagnosed by transbronchial mediastinal cryobiopsy using a \u00f81.7\u2009mm cryoprobe. The diagnosis was established in accordance with the 2020 revised comprehensive diagnostic criteria for IgG4\u2010RD, after exclusion of infectious and lymphoproliferative disorders. Endoscopic mediastinal cryobiopsy may represent a valuable and minimally invasive strategy for diagnosing mediastinal diseases.<\/jats:p>","DOI":"10.1002\/rcr2.70396","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:26:46Z","timestamp":1767842806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolated Mediastinal and Hilar Lymphadenopathy as a Manifestation of\n                    <scp>IgG4<\/scp>\n                    \u2010Related Disease Diagnosed by\n                    <scp>EBUS<\/scp>\n                    \u2010Guided Transbronchial Mediastinal Cryobiopsy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7122-8606","authenticated-orcid":false,"given":"Wen","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Respiratory Diseases, Department of Pulmonary and Critical Care Medicine Xinqiao Hospital, Army Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zansheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Diseases, Department of Pulmonary and Critical Care Medicine Xinqiao Hospital, Army Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[{"name":"The First People's Hospital of Kaili  Kaili Guizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanxiang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology Xinqiao Hospital, Army Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Diseases, Department of Pulmonary and Critical Care Medicine Xinqiao Hospital, Army Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guansong","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Diseases, Department of Pulmonary and Critical Care Medicine Xinqiao Hospital, Army Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Diseases, Department of Pulmonary and Critical Care Medicine Xinqiao Hospital, Army Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1199-6635","authenticated-orcid":false,"given":"Zhi","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Diseases, Department of Pulmonary and Critical Care Medicine Xinqiao Hospital, Army Medical University  Chongqing 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