{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T04:42:27Z","timestamp":1764132147232,"version":"3.46.0"},"reference-count":5,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Laryngo\u2010onycho\u2010cutaneous syndrome (LOCS), or Shabbir's syndrome, linked to mutations in the LAMA3 gene, is predominantly observed in children from Punjabi families. We present the case of a 2.5\u2010year\u2010old male who was initially misdiagnosed with asthma due to progressive hoarseness and stridor. Further evaluation revealed biphasic stridor, paronychia, conjunctival inflammation, nail dystrophy and widespread mucocutaneous lesions. Laryngoscopy showed glottic granulation tissue and subglottic stenosis. While genetic testing was unavailable due to resource limitations, histopathological findings supported a clinical diagnosis of LOCS. Through this case report, we aim to highlight the importance of considering LOCS diagnosis in children with atypical respiratory symptoms complemented by mucocutaneous findings, especially in atopy\u2010prone populations. Early diagnosis is critical to prevent complications like airway obstruction. Management remains supportive, involving surgical and ophthalmologic interventions.<\/jats:p>","DOI":"10.1002\/rcr2.70405","type":"journal-article","created":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T23:45:21Z","timestamp":1763336721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stridor Misleading as Asthma: Unveiling Case of Shabbir Syndrome in an Atopy\u2010Prone 2.5\u2009Years Old Pakistani"],"prefix":"10.1002","volume":"13","author":[{"given":"Nabeel","family":"Ahmad","sequence":"first","affiliation":[{"name":"Lahore General Hospital  Lahore Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Gohar","sequence":"additional","affiliation":[{"name":"Lahore General Hospital  Lahore Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Rehman Shahid","family":"Khan","sequence":"additional","affiliation":[{"name":"Lahore General Hospital  Lahore Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9012-5280","authenticated-orcid":false,"given":"Armaghan","family":"Hanif","sequence":"additional","affiliation":[{"name":"Ameer\u2010ud\u2010Din Medical College, PGMI\/LGH  Lahore Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohail","family":"Sani","sequence":"additional","affiliation":[{"name":"Shifa College of Medicine  Islamabad Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khizra","family":"Saeed","sequence":"additional","affiliation":[{"name":"Lahore General Hospital  Lahore Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8599-6861","authenticated-orcid":false,"given":"Masab","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Punjab Medical College  Faisalabad Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5248-0749","authenticated-orcid":false,"given":"Muhammad Husnain","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Tentishev Satkynbai Memorial Asian Medical Institute  Kant Kyrgyzstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fida","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Punjab Medical College  Faisalabad Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14790"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3126\/nepjoph.v11i1.25446"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2023.11.021"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07464.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.10.1435"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T04:38:11Z","timestamp":1764131891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":5,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/rcr2.70405"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70405","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70405"}}