{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:23:12Z","timestamp":1768285392899,"version":"3.49.0"},"reference-count":4,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tepotinib, a mesenchymal epithelial transition factor (MET) tyrosine kinase inhibitor, is used to treat non\u2010small cell lung cancer with MET exon 14 skipping mutations. Although hepatotoxicity has been reported, drug\u2010induced cholangitis has not been reported before. Here, we report a case of tepotinib\u2010induced cholangitis in a 77\u2010year\u2010old woman with preexisting primary biliary cholangitis. During tepotinib treatment, the patient experienced abdominal pain along with elevated hepatobiliary enzyme levels. Imaging and histological examinations revealed findings similar to sclerosing cholangitis. The liver enzyme levels decreased after drug discontinuation. This case highlights the need for careful monitoring of hepatobiliary function when prescribing MET inhibitors, particularly in patients with underlying liver disease.<\/jats:p>","DOI":"10.1002\/rcr2.70406","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:10:00Z","timestamp":1762902600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tepotinib\u2010Induced Cholangitis in a Patient With Non\u2010Small Cell Lung Cancer: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8341-9381","authenticated-orcid":false,"given":"Yoshimasa","family":"Hachisu","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Maebashi Red Cross Hospital  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kojiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maebashi Red Cross Hospital  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Hosino","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maebashi Red Cross Hospital  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Maebashi Red Cross Hospital  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Uno","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maebashi Red Cross Hospital  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuma","family":"Ezawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maebashi Red Cross Hospital  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Maebashi Red Cross Hospital  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maebashi Red Cross Hospital  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-2733"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2016.08.015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2023.100563"},{"key":"e_1_2_9_5_1","unstructured":"Pharmaceutical Evaluation Division P \u201cSafety and Environmental Health Bureau Ministry of Health Law \u201d 2020Report on the Deliberation Results https:\/\/www.pmda.go.jp\/files\/000236338.pdf."}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T04:38:12Z","timestamp":1764131892000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":4,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/rcr2.70406"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70406","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70406"}}