{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T04:41:23Z","timestamp":1764132083626,"version":"3.46.0"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mature teratomas are typically benign germ cell tumours (\n                    <jats:styled-content style=\"fixed-case\">GCT<\/jats:styled-content>\n                    ), but in rare cases, they can undergo malignant transformation. Malignant transformation of a mediastinal teratoma into adenocarcinoma is extremely rare and often poses diagnostic and therapeutic challenges. A 38\u2010year\u2010old male with a 14\u2010year history of a mature mediastinal teratoma, developed a mediastinal adenocarcinoma. The patient initially underwent surgical resection of the teratoma, with no evidence of malignancy at that time. Over the years, the patient remained asymptomatic until the recent onset of cough, prompting further investigation. Imaging studies revealed a recurrent mediastinal mass, and subsequent biopsy confirmed adenocarcinoma arising from the previously diagnosed teratoma. The patient underwent debulking thoracotomy and chemotherapy. This case highlights the importance of long\u2010term follow\u2010up in patients with mediastinal teratomas, given the rare but significant risk of malignant transformation. Awareness of this possibility can facilitate early diagnosis and timely intervention, ultimately improving patient outcomes.\n                  <\/jats:p>","DOI":"10.1002\/rcr2.70410","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T15:09:16Z","timestamp":1763132956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arising Mediastinal Adenocarcinoma in A Patient With A 14\u2009Years History of Mature Teratoma"],"prefix":"10.1002","volume":"13","author":[{"given":"Yanis Widhiya","family":"Ningrum","sequence":"first","affiliation":[{"name":"Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Airlangga University  Surabaya Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4627-0511","authenticated-orcid":false,"given":"Isnin Anang","family":"Marhana","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Airlangga University  Surabaya Indonesia"},{"name":"Department of Pulmonology and Respiratory Medicine Dr. Soetomo General Academic Hospital  Surabaya Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah","family":"Fatmawati","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Airlangga University  Surabaya Indonesia"},{"name":"Department of Pulmonology and Respiratory Medicine Dr. Soetomo General Academic Hospital  Surabaya Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"volume-title":"Fishman's Pulmonary Diseases and Disorders","year":"2023","author":"Fishman J. 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