{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T19:26:16Z","timestamp":1766949976516,"version":"3.48.0"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We report a case of wild\u2010type transthyretin amyloidosis (ATTRwt) in a 91\u2010year\u2010old female who developed alveolar hypoventilation despite improvement in heart failure. The patient presented with dyspnea and lower extremity edema, and was diagnosed with heart failure.\n                    <jats:sup>99<\/jats:sup>\n                    \u1d50Tc\u2010pyrophosphate scintigraphy scan showed cardiac uptake consistent with transthyretin amyloidosis, and genetic testing confirmed wild\u2010type disease. While cardiac symptoms improved with treatment, hypercapnia persisted, prompting pulmonology consultation. Chest radiographs and dynamic magnetic resonance imaging during inspiration and expiration revealed impaired diaphragmatic movement. A chest computed tomography scan showed no significant abnormal findings in the lung fields. Pulmonary function tests revealed mixed ventilatory impairment with preserved total lung capacity but increased residual volume. Maximum inspiratory and expiratory pressures were significantly decreased. Ultrasound evaluation revealed diaphragmatic weakness with minimal thickening during inspiration. Phrenic nerve conduction studies were normal. This case represents the first report of alveolar hypoventilation due to diaphragmatic dysfunction in ATTRwt.\n                  <\/jats:p>","DOI":"10.1002\/rcr2.70422","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T12:29:41Z","timestamp":1764419381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wild\u2010Type Transthyretin Amyloidosis Complicated by Alveolar Hypoventilation due to Diaphragmatic Dysfunction"],"prefix":"10.1002","volume":"13","author":[{"given":"Mayumi","family":"Aoyama","sequence":"first","affiliation":[{"name":"Respiratory Disease Center Tokyo General Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Takezawa","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Tokyo General Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rino","family":"Arai","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Tokyo General Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saya","family":"Hattori","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Tokyo General Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Nakano","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Tokyo General Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo General Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoki","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo General Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenobu","family":"Shigemitsu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine St. Rose Dominican Siena Hospital  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8147-8983","authenticated-orcid":false,"given":"Ichiro","family":"Kuwahira","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Tokyo General Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-20-0110"},{"key":"e_1_2_9_3_1","article-title":"Age\u2010Related Changes in Static Maximal Inspiratory and Expiratory Pressures","volume":"35","author":"Suzuki M.","year":"1997","journal-title":"Nihon Ky\u014dbu Shikkan Gakkai Zasshi"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2022.07.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.5.9154859"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.12.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.000132"},{"key":"e_1_2_9_8_1","article-title":"A Case of Fatal Respiratory Failure Caused by Diaphragmatic Amyloidosis","volume":"199","author":"Moffitt K. M.","year":"2019","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100017431"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2022.01.006"},{"key":"e_1_2_9_11_1","first-page":"63","article-title":"Neuromuscular Amyloidosis","volume":"21","author":"Pinto L. F.","year":"2021","journal-title":"Practical Neurology"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T19:24:29Z","timestamp":1766949869000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,29]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/rcr2.70422"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70422","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2025,11,29]]},"assertion":[{"value":"2025-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70422"}}