{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T19:26:20Z","timestamp":1766949980032,"version":"3.48.0"},"reference-count":5,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Inflammatory myofibroblastic tumours (IMT) are rare mesenchymal neoplasms that account for less than 1% of all lung tumours. Although ~50%\u201360% of IMT cases are anaplastic lymphoma kinase (ALK)\u2010positive, ALK\u2010negative IMT cases present diagnostic challenges owing to diverse pathological features. Here, we report a rare case of a rapidly growing ALK\u2010negative, neurotrophic tyrosine receptor kinase 3 (NTRK3)\u2010positive pulmonary IMT in a 46\u2010year\u2010old man with a history of pulmonary tuberculosis. A 13\u2010mm nodule detected during routine screening grew to 18\u2009mm within 1\u2009month. Complete surgical resection was performed by video\u2010assisted thoracic surgery. Histopathological examination revealed spindle cell proliferation with inflammatory cell infiltration. Immunohistochemistry was negative for ALK; however, molecular analysis identified an ETV6\u2010NTRK3 fusion gene. The patient remains disease\u2010free at 9\u2009months postoperatively. This case highlights the importance of comprehensive molecular testing in ALK\u2010negative IMT and demonstrates that complete surgical resection can achieve excellent outcomes even in rapidly growing lesions.<\/jats:p>","DOI":"10.1002\/rcr2.70427","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T02:14:11Z","timestamp":1765246451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapidly Growing\n                    <scp>ALK<\/scp>\n                    \u2010Negative\n                    <scp>NTRK3<\/scp>\n                    \u2010Positive Inflammatory Myofibroblastic Tumour of the Lung"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1226-2795","authenticated-orcid":false,"given":"Yukitaka","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery St. Luke's International Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumitsugu","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery St. Luke's International Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Ushigusa","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Luke's International Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsaku","family":"Kabemura","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery St. Luke's International Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torahiko","family":"Jinta","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine St. Luke's International Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Bando","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery St. Luke's International Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17081327"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025972"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjon.2023.12.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.826705"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30691-6"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T19:24:40Z","timestamp":1766949880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":5,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/rcr2.70427"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70427","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70427"}}