{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T19:26:19Z","timestamp":1766949979130,"version":"3.48.0"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Thymoma is a rare thymic epithelial tumour, often detected incidentally on imaging. We report a 30\u2010year\u2010old female presenting with cough and chest discomfort, whose evaluation revealed a large anterior mediastinal mass compressing the heart and\u00a0superior vena cava. Histopathology confirmed type B3 thymoma. The patient underwent thymectomy with residual disease, followed by adjuvant radiotherapy and prolonged pembrolizumab immunotherapy. Serial imaging demonstrated\u00a0marked tumour regression, with residual metabolically inactive tissue on PET scan, consistent with non\u2010viable remnants. This favourable outcome is notable given the incomplete (R2) resection, where prognosis is typically poor. The case illustrates the effectiveness of a multimodal approach incorporating immune checkpoint blockade in advanced thymoma, an area with limited clinical evidence. Reports on pembrolizumab use after incomplete thymectomy remain limited in the global literature, and this case highlights its potential role in extending disease control and improving outcomes in aggressive thymoma.<\/jats:p>","DOI":"10.1002\/rcr2.70433","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T05:47:50Z","timestamp":1765259270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Inoperable to Remission: Complete Response in Advanced Thymoma\n                    <scp>B3<\/scp>\n                    With Immunotherapy\u2014A Case Report"],"prefix":"10.1002","volume":"13","author":[{"given":"Dharmaning Estu","family":"Wirastyo","sequence":"first","affiliation":[{"name":"Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Airlangga \u2010 Dr. Soetomo General Academic Hospital  Surabaya Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4627-0511","authenticated-orcid":false,"given":"Isnin Anang","family":"Marhana","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Airlangga \u2010 Dr. Soetomo General Academic Hospital  Surabaya Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-996X","authenticated-orcid":false,"given":"Alfian Nur","family":"Rosyid","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Airlangga \u2010 Dr. Soetomo General Academic Hospital  Surabaya Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"355","article-title":"Thymoma Recurrence and Its Predisposing Factors in Iranian Population: A Single Center Study","volume":"18","author":"Seifi S.","year":"2019","journal-title":"Tanaffos"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.3389\/fsurg.2022.984043"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1177\/1073274819865281"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1186\/s13019\u2010020\u201001320\u2010x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.21037\/tlcr\u201020\u2010458"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1016\/S1470-2045(18)30062-7"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1200\/JCO.2017.77.3184"},{"volume-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Thymomas and Thymic Carcinomas. Version 2.2024. Plymouth Meeting, PA","year":"2024","author":"National Comprehensive Cancer Network","key":"e_1_2_10_9_1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.3390\/biomedicines12092106"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.3390\/cancers16172966"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1016\/j.jtocrr.2020.100011"},{"volume-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Thymomas and Thymic Carcinomas","year":"2022","author":"Gregory K.","key":"e_1_2_10_13_1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.3390\/cancers15071953"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T19:24:37Z","timestamp":1766949877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/rcr2.70433"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70433","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70433"}}