{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T09:39:01Z","timestamp":1770111541131,"version":"3.49.0"},"reference-count":5,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pneumocystis jirovecii pneumonia (PJP) is a life\u2010threatening opportunistic infection typically seen in immunocompromised patients. It is rarely reported during standard systemic therapy for prostate cancer. A 75\u2010year\u2010old man with low\u2010volume metastatic hormone\u2010sensitive prostate cancer (mHSPC) received triplet therapy with relugolix, darolutamide and docetaxel. He had well\u2010controlled diabetes and no history of immunosuppression. After the second docetaxel cycle, he developed anorexia. Chest CT revealed bilateral ground\u2010glass opacities. \u03b2\u2010D\u2010glucan was elevated, and sputum PCR detected P. jirovecii DNA. Despite appropriate trimethoprim\u2010sulfamethoxazole and corticosteroid therapy, he died of respiratory failure ~10\u2009days after symptom onset. This case highlights an underrecognized risk of PJP during triplet therapy for mHSPC. Prophylaxis should be considered in select high\u2010risk patients, including elderly individuals or those with metabolic comorbidities.<\/jats:p>","DOI":"10.1002\/rcr2.70435","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T04:13:32Z","timestamp":1765253612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unexpected Fatal Pneumocystis Jirovecii Pneumonia During Triplet Therapy for Hormone\u2010Sensitive Prostate Cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7240-6113","authenticated-orcid":false,"given":"Fumihiro","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Urology Gifu Prefectural Tajimi Hospital  Tajimi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu Prefectural Tajimi Hospital  Tajimi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaku","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu Prefectural Tajimi Hospital  Tajimi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Kamijo","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu Prefectural Tajimi Hospital  Tajimi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu Prefectural Tajimi Hospital  Tajimi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2119115"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00367-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032588"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-012-0408-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000915)89:6<1380::AID-CNCR23>3.0.CO;2-R"}],"updated-by":[{"DOI":"10.1002\/rcr2.70484","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000}}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T19:24:36Z","timestamp":1766949876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":5,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/rcr2.70435"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70435","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70435"}}