{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:03:39Z","timestamp":1768277019083,"version":"3.49.0"},"reference-count":4,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Intravesical Bacillus Calmette\u2013Guerin (BCG) therapy is the standard treatment for non\u2013muscle\u2010invasive bladder cancer. While it is effective, it sometimes causes a disseminated BCG infection, which is often difficult to diagnose microbiologically. We report herein a 73\u2010year\u2010old, male patient in whom a persistent fever, dyspnoea, and jaundice developed after he received his tenth round of intravesical BCG therapy. Chest computed tomography revealed diffuse micronodules, and lung and liver biopsies demonstrated multiple, well\u2010formed, non\u2010caseating granulomas. Despite negative microbiological test results, a disseminated BCG infection was suspected. Antimycobacterial therapy was started but discontinued after 2\u2009weeks due to a drug\u2010induced eruption. The clinical and radiological findings continued to improve without further treatment. The present case highlights the importance of a detailed assessment of radiological and histopathological findings for the diagnosis and management of diffuse lung diseases, including complications related to intravesical BCG therapy.<\/jats:p>","DOI":"10.1002\/rcr2.70448","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T12:52:26Z","timestamp":1766062346000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostically Challenging Disseminated Bacillus Calmette\u2013Guerin Infection With Lung and Liver Involvement: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0350-0565","authenticated-orcid":false,"given":"Shinichi","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1616-9893","authenticated-orcid":false,"given":"Makiko","family":"Yomota","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of General Medicine Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyo","family":"Yanagawa","sequence":"additional","affiliation":[{"name":"Department of Radiology Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsunekazu","family":"Hishima","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of General Medicine Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3849-5905","authenticated-orcid":false,"given":"Yukio","family":"Hosomi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003846"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000119"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2020.12.025"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1092-9134(02)91219-0"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T19:24:43Z","timestamp":1766949883000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":4,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/rcr2.70448"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70448","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70448"}}