{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:48:57Z","timestamp":1769539737686,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Endometrial carcinoma is the most common gynecologic malignancy in developed countries and is typically diagnosed at an early stage, with distant metastases uncommon at presentation. Pulmonary involvement occurs in less than 5% of cases and usually manifests as small nodules or interstitial disease; the appearance of multiple, large, round \u2018cannonball\u2019 metastases is exceptionally rare. We report the case of a 60\u2010year\u2010old woman who presented with cough and dyspnea. Imaging revealed numerous bilateral pulmonary \u2018cannonball\u2019 nodules, mediastinal lymphadenopathy, hepatic lesions, and an enlarged uterus. Endometrial biopsy confirmed endometrioid adenocarcinoma, staged as FIGO IV\u2010B. The patient underwent chemotherapy with carboplatin and paclitaxel, resulting in significant regression of pulmonary and hepatic metastases and symptomatic improvement, followed by maintenance therapy with anastrozole that achieved stable disease on surveillance. This case highlights the importance of recognising cannonball pulmonary metastases as a potential, albeit rare, initial presentation of endometrial carcinoma, thereby guiding timely diagnosis and treatment.<\/jats:p>","DOI":"10.1002\/rcr2.70455","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T23:10:02Z","timestamp":1767654602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cannonball Metastases of the Lung: An Unusual Initial Manifestation of Endometrial Carcinoma"],"prefix":"10.1002","volume":"14","author":[{"given":"Midila","family":"Bapineni","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Appalachian Regional Healthcare  Harlan Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivendra","family":"Tangutoori","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Appalachian Regional Healthcare  Harlan Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naga Vamsi Krishna","family":"Machineni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Appalachian Regional Healthcare  Harlan Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamlesh","family":"Sajnani","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Appalachian Regional Healthcare  Harlan Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4334-6696","authenticated-orcid":false,"given":"Maneesh","family":"Gaddam","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Critical Care and Sleep Medicine Appalachian Regional Healthcare  Hazard Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2016.1127351"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100142(19960801)78:3<>3.0.CO;2\u2010Z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525\u20101438.2002.01095.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102012\u2010008158"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970\u20102113.156264"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.21.4.g01jl03825"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970\u20102113.188988"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_280495"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201011\u20100039"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15215123"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70455","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T05:43:18Z","timestamp":1769492598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/rcr2.70455"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70455","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70455"}}