{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:45:34Z","timestamp":1787496334671,"version":"build-2736575974"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A 66\u2010year\u2010old man with a 20\u2010year history of recurrent haemoptysis presented with mild bronchiectasis and linear opacities detected on chest computed tomography (CT). The lesion was followed up annually and gradually enlarged into a mass over 10\u2009years. Multiple bilateral pulmonary nodules were noted at 78\u2009years of age. Surgical biopsy revealed malignant melanoma without evidence of other primary lesions on dermatological examination or positron emission tomography\u2010CT. The patient was treated with nivolumab and achieved stable disease for 8\u2009months before discontinuation owing to immune\u2010related adverse events. Rapid disease progression was observed, and the patient died 14\u2009months after initiating immunotherapy. Autopsy demonstrated extensive metastatic dissemination and marked tumour necrosis with CD8+ T\u2010cell infiltration in the lung tumour, indicating a therapeutic response to nivolumab. These findings highlight the potential association between chronic airway inflammation and tumour development and suggest that immunotherapy could play a role in treating PMML.<\/jats:p>","DOI":"10.1002\/rcr2.70464","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:10:32Z","timestamp":1768435832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Primary Malignant Melanoma of the Lung With a Long\u2010Term Course: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Yusei","family":"Fukushima","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Osaka Saiseikai Nakatsu Hospital  Osaka City Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6049-9161","authenticated-orcid":false,"given":"Masanori","family":"Azuma","sequence":"additional","affiliation":[{"name":"Department of 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Unlikely Source","volume":"5","author":"McNab P.","year":"2012","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412082"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2024.102161"}],"container-title":["Respirology Case 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