{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:25:01Z","timestamp":1769538301032,"version":"3.49.0"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>IgG4\u2010related disease (IgG4\u2010RD) is a fibroinflammatory disease characterised by elevated serum IgG4 levels and marked infiltration of IgG4\u2010positive plasma cells. Here, we present the case of a 49\u2010year\u2010old man who presented with dysphagia and hoarseness caused by an anterior mediastinal mass. As the fluorodeoxyglucose positron emission tomography (FDG\u2010PET) SUVmax was 6.68 (early and delayed), malignancy was initially suspected. Serum IgG4 levels were slightly elevated at 148\u2009mg\/dL. Surgical biopsy revealed dense lymphoplasmacytic infiltration with storiform fibrosis and numerous IgG4\u2010positive plasma cells, fulfilling the diagnostic criteria for IgG4\u2010RD. Treatment with high\u2010dose prednisolone (60\u2009mg\/day) rapidly resolved symptoms and markedly reduced the mass within 6\u2009months. This case highlights the importance of considering IgG4\u2010RD in the differential diagnosis of mediastinal tumours, even when FDG\u2010PET shows abnormal accumulation and serum IgG4 levels are not particularly high.<\/jats:p>","DOI":"10.1002\/rcr2.70468","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T20:44:44Z","timestamp":1769460284000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of\n                    <scp>IgG4<\/scp>\n                    \u2010Related Disease That Mimics an Anterior Mediastinal Malignant Tumour"],"prefix":"10.1002","volume":"14","author":[{"given":"Noriaki","family":"Nishimura","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Mibu Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-5750","authenticated-orcid":false,"given":"Yusuke","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Mibu Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Yazawa","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Mibu Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Mibu Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonari","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Mibu Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Dokkyo Medical University, School of Medicine  Mibu Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Dokkyo Medical University School of Medicine  Mibu Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0574-9611","authenticated-orcid":false,"given":"Kei","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Dokkyo Medical University School of Medicine  Mibu Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Takemasa","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Mibu Tochigi Japan"},{"name":"Respiratory Endoscopy Center Dokkyo Medical University Hospital  Mibu Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Chida","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Dokkyo Medical University, School of Medicine  Mibu Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2804-4588","authenticated-orcid":false,"given":"Kazuyuki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Dokkyo Medical University School of Medicine  Mibu Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Mibu Tochigi Japan"},{"name":"Respiratory Endoscopy Center Dokkyo Medical University Hospital  Mibu Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9480-5923","authenticated-orcid":false,"given":"Seiji","family":"Niho","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Mibu Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.787422"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2020.1859710"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41120"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214603"},{"issue":"1","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s13075-020-02338-1","article-title":"Serum IgE in the Clinical Features and Disease Outcomes of IgG4\u2010Related Disease: A Large Retrospective Cohort Study","volume":"22","author":"Zhou J.","year":"2020","journal-title":"Arthritis Research & Therapy"}],"container-title":["Respirology Case 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