{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:46:14Z","timestamp":1769539574403,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Acute exacerbation of interstitial pneumonia (IP\u2010AE) is a type of severe respiratory failure that occurs in patients with chronic interstitial pneumonia. Herein, we report a case of multiple pulmonary thrombi caused by antiphospholipid antibody syndrome (\n APS<\/jats:styled-content>\n ), which required differentiation from\n IP<\/jats:styled-content>\n \u2010\n AE<\/jats:styled-content>\n in a patient with chronic interstitial pneumonia. A 77\u2010year\u2010old male patient presented with acute respiratory failure and bilateral ground\u2010glass opacities on chest computed tomography (\n CT<\/jats:styled-content>\n ), which initially indicated\n IP<\/jats:styled-content>\n \u2010\n AE<\/jats:styled-content>\n . However, the contrast\u2010enhanced\n CT<\/jats:styled-content>\n scan revealed multiple pulmonary thrombi, and the laboratory examination showed positivity for antiphospholipid antibodies. The patient was diagnosed with\n APS<\/jats:styled-content>\n and was successfully treated with anticoagulant therapy and systemic corticosteroids. The pulmonary manifestations of\n APS<\/jats:styled-content>\n may mimic those of\n IP<\/jats:styled-content>\n \u2010\n AE<\/jats:styled-content>\n and may be under\u2010recognised. Thus,\n APS<\/jats:styled-content>\n should be considered in the differential diagnosis of acute respiratory deterioration in patients with interstitial pneumonia.\n <\/jats:p>","DOI":"10.1002\/rcr2.70473","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T10:10:03Z","timestamp":1768385403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antiphospholipid Syndrome Mimicking Acute Exacerbation of Interstitial Pneumonia: A Case Report and Literature Review"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5620-4385","authenticated-orcid":false,"given":"Saki","family":"Ishii","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center Chiba 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