{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:02:49Z","timestamp":1789639369298,"version":"4.0.0"},"reference-count":4,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n NUT<\/jats:styled-content>\n carcinoma is a rare and highly aggressive malignancy, particularly when arising in the thorax. Radiotherapy is commonly used for symptom palliation; however, radiotherapeutic response patterns in thoracic\n NUT<\/jats:styled-content>\n carcinoma remain poorly characterised. We report a 22\u2010year\u2010old woman with thoracic\n NUT<\/jats:styled-content>\n carcinoma who demonstrated markedly heterogeneous responses to palliative radiotherapy across metastatic sites. A thoracic lesion causing superior vena cava (\n SVC<\/jats:styled-content>\n ) syndrome showed sustained radiographic improvement after irradiation, whereas a pelvic bone metastasis progressed shortly after single\u2010fraction radiotherapy despite transient symptom relief. Although differences in delivered radiation dose likely contributed to these outcomes, this case illustrates practical considerations in palliative radiotherapy for thoracic\n NUT<\/jats:styled-content>\n carcinoma, including effective symptom control for\n SVC<\/jats:styled-content>\n syndrome and the limited durability of single\u2010fraction radiotherapy for bone metastases. This case highlights practical considerations in palliative radiotherapy for thoracic\n NUT<\/jats:styled-content>\n carcinoma and provides an educational perspective for respiratory physicians involved in multidisciplinary cancer care.\n <\/jats:p>","DOI":"10.1002\/rcr2.70475","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:20:53Z","timestamp":1768436453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Radiotherapy Response Patterns in Thoracic\n NUT<\/scp>\n Carcinoma: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0214-1571","authenticated-orcid":false,"given":"Fumihiro","family":"Kashizaki","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Yokohama Minami Kyosai Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9019-2784","authenticated-orcid":false,"given":"Nanami","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Yokohama Minami Kyosai Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Yokohama Minami Kyosai Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanming","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Yokohama Minami Kyosai Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0393-4388","authenticated-orcid":false,"given":"Ryusuke","family":"Orii","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Yokohama Minami Kyosai Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Yumoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Yokohama Minami Kyosai Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1418-5152","authenticated-orcid":false,"given":"Yoshiyuki","family":"Yasuura","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Yokohama Minami Kyosai Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Pathology Yokohama Minami Kyosai Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5384-9288","authenticated-orcid":false,"given":"Hiroyuki","family":"Osawa","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Yokohama Minami Kyosai Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6406-6138","authenticated-orcid":false,"given":"Harumi","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Yokohama Minami Kyosai Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Yokohama Minami Kyosai Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","article-title":"International Guidelines on the Diagnosis and Treatment of NUT Carcinoma","volume":"7","author":"Zhang Y.","year":"2025","journal-title":"Innovation"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-62-740-679"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/clon.2001.9221"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26570-8"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70475","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70475","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T05:43:19Z","timestamp":1769492599000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":4,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/rcr2.70475"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70475","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70475"}}