{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:46:02Z","timestamp":1769539562660,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Methicillin\u2010susceptible\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    (MSSA) necrotizing pneumonia can progress to severe disease, particularly when Panton\u2013Valentine leukocidin (PVL) is involved. Here we report the case of a previously healthy 56\u2010year\u2010old man who developed severe necrotizing pneumonia due to MSSA despite the absence of major toxin genes including PVL. The patient reported a 10\u2010day history of low\u2010grade fever and was admitted for bilateral pneumonia with sepsis. Despite antibiotic therapy, his condition rapidly progressed, and chest computed tomography revealed extensive ground\u2010glass opacities and multiple cavitary lesions. MSSA was isolated from blood and pleural fluid cultures, and polymerase chain reaction confirmed negativity for PVL, toxic shock syndrome toxin\u20101, and exfoliative toxin genes. Although the infection improved with antibiotics including clindamycin, a potent toxin suppressor, the patient experienced recurrent refractory pneumothorax due to persistent cavitary lesions that led to prolonged respiratory failure. PVL\u2010negative MSSA necrotizing pneumonia can be a life\u2010threatening disease with long\u2010term complications.\n                  <\/jats:p>","DOI":"10.1002\/rcr2.70488","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T04:58:47Z","timestamp":1769057927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Necrotizing Pneumonia Caused by\n                    <scp>PVL<\/scp>\n                    \u2010Negative Methicillin\u2010Susceptible\n                    <i>Staphylococcus aureus<\/i>\n                    Complicated by Refractory Pneumothorax: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8836-7517","authenticated-orcid":false,"given":"Shun","family":"Endo","sequence":"first","affiliation":[{"name":"Department of Pulmonology Soka Municipal Hospital  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoka","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Soka Municipal Hospital  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Soka Municipal Hospital  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Shimaya","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Soka Municipal Hospital  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Tsukada","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Soka Municipal Hospital  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07877-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13110984"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-222542"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.894022"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12943"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1581ST"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.01.030"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005337"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-22-1590"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.02.020"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.70053"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70488","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T05:42:59Z","timestamp":1769492579000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/rcr2.70488"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70488","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70488"}}