{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T14:02:29Z","timestamp":1775570549359,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A 52\u2010year\u2010old man with chronic myeloid leukaemia (CML) who had been receiving dasatinib 100\u2009mg\/day for 13\u2009years presented with progressive dyspnea. Chest radiography revealed bilateral pleural effusions, and further evaluation confirmed the diagnosis of chylothorax. Dasatinib\u2010induced chylothorax was suspected, and discontinuation of the drug led to clinical improvement. Dasatinib is a tyrosine kinase inhibitor (TKI) used for the treatment of CML and Philadelphia chromosome\u2013positive acute lymphoblastic leukaemia (Ph\u2009+\u2009ALL). Although pleural effusion is a relatively common adverse effect, chylothorax is an extremely rare complication. This case highlights the importance of considering chylothorax as a potential cause of pleural effusion in patients undergoing long\u2010term dasatinib therapy. In addition, based on the presumed pathophysiological mechanism, drug discontinuation appears to be the most crucial therapeutic approach for dasatinib\u2010induced chylothorax.<\/jats:p>","DOI":"10.1002\/rcr2.70529","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:19:46Z","timestamp":1772993986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bilateral Chylothorax After 13\u2009Years of Dasatinib Therapy in a Patient With Chronic Myeloid Leukaemia: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8076-1373","authenticated-orcid":false,"given":"Riku","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010ichiro","family":"Iwakami","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manami","family":"Haba","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Iwakami","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Fujikawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.8899"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24734"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000041328"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.12890\/2022_003601"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01096-2017"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70529","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70529","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:17:24Z","timestamp":1774585044000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/rcr2.70529"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70529","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2026-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70529"}}