{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T14:03:25Z","timestamp":1775570605675,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dasatinib, a second\u2010generation tyrosine kinase inhibitor, is highly effective in chronic myeloid leukaemia (CML) but is associated with pleural complications in approximately 28%\u201337% of patients. We report four patients with CML who developed dasatinib\u2010induced pleural effusion after prolonged treatment (2\u201310\u2009years), including one case of chylothorax. All presented with dyspnea, and imaging with diagnostic thoracentesis confirmed exudative pleural effusions. One patient demonstrated triglyceride\u2010rich fluid consistent with chylothorax. Dose reduction of dasatinib to 50\u2009mg\/day led to complete clinical and radiological resolution in three patients while maintaining molecular remission. The fourth patient encountered recurrent chylothorax despite dosage modification and supportive therapy, necessitating permanent discontinuation of dasatinib and transition to nilotinib, resulting in sustained radiological resolution and continued molecular response. This case series highlights the spectrum of late\u2010onset dasatinib\u2010related pleural complications and demonstrates that timely dose modification or TKI switching can effectively manage toxicity while preserving oncological outcomes.<\/jats:p>","DOI":"10.1002\/rcr2.70532","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:49:14Z","timestamp":1773028154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dasatinib Associated Pleural Complications\u2010 A Case Series"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3779-7347","authenticated-orcid":false,"given":"Vishnu","family":"Vazhoor","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Amrita Institute of Medical Science and Research Centre  Kochi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shruthi Keechilat","family":"Pavithran","sequence":"additional","affiliation":[{"name":"Department of Pathology Amrita\u00a0Institute of Medical Science and Research Centre  Kochi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Unni","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Amrita Institute of Medical\u00a0Science\u00a0and Research Centre  Kochi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2937-0454","authenticated-orcid":false,"given":"Asmita","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Amrita Institute of Medical Science and Research Centre  Kochi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keechilat","family":"Pavithran","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Amrita Institute of Medical Science and Research Centre  Kochi 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