{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T05:56:51Z","timestamp":1774591011247,"version":"3.50.1"},"reference-count":6,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A 52\u2010year\u2010old man with a history of Philadelphia chromosome\u2010positive acute lymphoblastic leukaemia underwent peripheral blood stem cell transplantation (PBSCT) 10\u2009years earlier. Five years after transplantation, he developed a persistent dry cough and exertional dyspnea. High\u2010resolution CT revealed upper lobe\u2010predominant subpleural fibrosis compatible with pleuroparenchymal fibroelastosis (PPFE) and lower lobe reticulation with ground\u2010glass opacities. Video\u2010assisted thoracoscopic lung biopsy showed subpleural fibroelastosis and bronchocentric lesions, along with intra\u2010alveolar accumulation of foamy macrophages containing cholesterol crystals and periodic acid\u2013Schiff\u2010positive material, with surfactant protein A immunoreactivity\u2014consistent with pulmonary alveolar proteinosis (PAP). Despite corticosteroids, tacrolimus, and subsequent antifibrotic therapy with nintedanib, the disease gradually progressed, and the patient ultimately died of acute exacerbation triggered by SARS\u2010CoV\u20102 infection. This case highlights a rare coexistence of PPFE and PAP after PBSCT and underscores the potential role of chronic graft\u2010versus\u2010host disease and immune dysregulation in their pathogenesis.<\/jats:p>","DOI":"10.1002\/rcr2.70536","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T01:32:03Z","timestamp":1773106323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pleuroparenchymal Fibroelastosis Complicated by Pulmonary Alveolar Proteinosis After Peripheral Blood Stem Cell Transplantation"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3688-6782","authenticated-orcid":false,"given":"Keishi","family":"Sugino","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Tsuboi Hospital  Koriyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9090-506X","authenticated-orcid":false,"given":"Hirotaka","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tsuboi Hospital  Koriyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikako","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tsuboi Hospital  Koriyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Tsuboi Hospital  Koriyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Igarashib","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Tsuboi Hospital  Koriyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Hebisawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo National Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3289"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00214713"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.321"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.298"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00092910"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0066-3"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70536","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:17:06Z","timestamp":1774585026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/rcr2.70536"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70536","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2026-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70536"}}