{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:10:37Z","timestamp":1785240637436,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cystic fibrosis (CF) modulator therapies can lead to rapid and excessive weight gain. Obesity in CF can lead to undesirable metabolic complications including type 2 diabetes. Therefore, glucagon\u2010like peptide 1 (GLP\u20101) agonists which can facilitate weight loss and improve metabolic profiles are increasingly prescribed to people with CF. We present the first case report documenting serial changes in body composition and bone mineral density over a 3\u2010year period in an adult with CF, obesity and diabetes treated with Semaglutide and Elexacaftor\/Tezacaftor\/Ivacaftor (ETI). Our case experienced substantial weight gain following ETI initiation which exacerbated hyperglycaemia. This prompted initiation of Semaglutide, which over 12\u2009months led to 14.8% total body weight loss and significant glycaemic improvement. However, serial assessments revealed declines in absolute muscle mass, muscle strength and bone mineral density despite prescription of tailored exercise and nutritional interventions. Our findings highlight the need for cautious use of GLP\u20101 in people with CF.<\/jats:p>","DOI":"10.1002\/rcr2.70541","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:56:15Z","timestamp":1773197775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Muscle Dysfunction and Bone Loss in a Woman With Cystic Fibrosis and Obesity Treated With Glucagon\u2010Like Peptide 1 Agonist: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5456-2699","authenticated-orcid":false,"given":"Shanal","family":"Kumar","sequence":"first","affiliation":[{"name":"The Adult Cystic Fibrosis Centre (ACFC), the Prince Charles Hospital, Chermside Queensland  Chermside Australia"},{"name":"The University of Queensland  St Lucia Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9954-1178","authenticated-orcid":false,"given":"Robyn","family":"Cobb","sequence":"additional","affiliation":[{"name":"The Adult Cystic Fibrosis Centre (ACFC), the Prince Charles Hospital, Chermside Queensland  Chermside Australia"},{"name":"Dept Physiotherapy Allied Health the Prince Charles Hospital, Chermside Queensland  Chermside Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8553-4786","authenticated-orcid":false,"given":"Angela","family":"Matson","sequence":"additional","affiliation":[{"name":"The Adult Cystic Fibrosis Centre (ACFC), the Prince Charles Hospital, Chermside Queensland  Chermside Australia"},{"name":"Dept Nutrition &amp; Dietetics Allied Health the Prince Charles Hospital, Chermside Queensland  Chermside Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Lee","sequence":"additional","affiliation":[{"name":"Dept Radiology, the Prince Charles Hospital, Chermside Queensland  Chermside Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Henderson","sequence":"additional","affiliation":[{"name":"The Adult Cystic Fibrosis Centre (ACFC), the Prince Charles Hospital, Chermside Queensland  Chermside Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2024.100375"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2025.10.006"},{"key":"e_1_2_10_4_1","unstructured":"\u201cAnnual Cystic Fibrosis Data Registry 2023 \u201d2023 https:\/\/www.cysticfibrosis.org.au\/wp\u2010content\/uploads\/2024\/07\/ACFDR_2023_Annual\u2010Report.pdf."},{"key":"e_1_2_10_5_1","unstructured":"\u201cCystic Fibrosis Foundation Patient Registry Annual Data Report 2023 \u201d2023 https:\/\/www.cff.org\/sites\/default\/files\/2024\u201009\/2023\u2010Patient\u2010Registry\u2010Annual\u2010Data\u2010Report.pdf."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1349253"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2021.06.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/db22-0399"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.07.005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-012-0434-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2016.10.001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2017.02.007"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2025.10.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001074"},{"key":"e_1_2_10_15_1","article-title":"Co\u2010Design, Implementation and Evaluation of a Nested Diabetes Model\u2010Of\u2010Care for Adults Living With Cystic Fibrosis","author":"Kumar S. 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