{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T05:56:59Z","timestamp":1774591019736,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004801","name":"Shota Rustaveli National Science Foundation","doi-asserted-by":"publisher","award":["22\u20102601"],"award-info":[{"award-number":["22\u20102601"]}],"id":[{"id":"10.13039\/501100004801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cystic fibrosis\u2010related diabetes (CFRD) is a common metabolic complication in adolescents with cystic fibrosis (CF). Variants in\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    and\n                    <jats:italic>SLC26A9<\/jats:italic>\n                    have been implicated in CFRD susceptibility. The coexistence of CF, CFRD, and celiac disease in childhood is rare and presents diagnostic and therapeutic challenges. We describe a 14\u2010year\u2010old female with CF carrying compound heterozygous\n                    <jats:italic>CFTR<\/jats:italic>\n                    mutations (p.Glu831Ter and\n                    <jats:italic>p.Ser573Phe<\/jats:italic>\n                    ). Sweat chloride values were borderline. At age 7, she was diagnosed with celiac disease after elevated anti\u2010tTG IgA (297\u2009U\/mL) and IgG (22.6\u2009U\/mL) and was started on a gluten\u2010free diet. At age 12\u2009years, she presented with diabetic ketoacidosis and was diagnosed with CFRD, requiring insulin therapy. Genotyping revealed high\u2010risk diabetes and CF\u2010modifier variants: rs7903146 TT (\n                    <jats:italic>TCF7L2<\/jats:italic>\n                    ) and rs4077468 GG (\n                    <jats:italic>SLC26A9<\/jats:italic>\n                    ). This case highlights the interplay of CF, autoimmunity, and genetic predisposition in early onset CFRD. Genetic profiling may improve risk assessment in CF patients with complex endocrine or autoimmune presentations.\n                  <\/jats:p>","DOI":"10.1002\/rcr2.70551","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:34:42Z","timestamp":1773722082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cystic Fibrosis\u2010Related Diabetes and Celiac Disease in a Paediatric\n                    <scp>CF<\/scp>\n                    Patient: Presence of\n                    <scp>CFRD<\/scp>\n                    \u2010Associated\n                    <scp>SNPs<\/scp>\n                    rs7903146 (\n                    <scp>TT<\/scp>\n                    ) and rs4077468 (\n                    <scp>GG<\/scp>\n                    )"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1200-0230","authenticated-orcid":false,"given":"Eka","family":"Kvaratskhelia","sequence":"first","affiliation":[{"name":"Department of Molecular and Medical Genetics Tbilisi State Medical University  Tbilisi Georgia"},{"name":"V. Bakhutashvili Institute of Medical Biotechnology Tbilisi State Medical University  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dodo","family":"Agladze","sequence":"additional","affiliation":[{"name":"Petre Shotadze Tbilisi Medical Academy  Tbilisi Georgia"},{"name":"Medical Genetics and Laboratory Diagnostics Center  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nino","family":"Vardosanidze","sequence":"additional","affiliation":[{"name":"Medical Genetics and Laboratory Diagnostics Center  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Ghughunishvili","sequence":"additional","affiliation":[{"name":"G. Zhvania Pediatric University Clinic Tbilisi State Medical University  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Surmava","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Genetics Tbilisi State Medical University  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elene","family":"Abzianidze","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Genetics Tbilisi State Medical University  Tbilisi Georgia"},{"name":"Ivane Beritashvili Center of Experimental Biomedicine  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tinatin","family":"Tkemaladze","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Genetics Tbilisi State Medical University  Tbilisi Georgia"},{"name":"G. Zhvania Pediatric University Clinic Tbilisi State Medical University  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13\u20100510"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2021.100287"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz102"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2010_2382"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20105448.2009.00587.x"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70551","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70551","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:17:17Z","timestamp":1774585037000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/rcr2.70551"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70551","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70551"}}