{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:02:36Z","timestamp":1783191756506,"version":"3.54.6"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Bronchiectasis predisposes patients to refractory airway infections and significantly reduces their quality of life. Here, we report a case of a 78\u2010year\u2010old woman with refractory\n \n Pseudomonas aeruginosa<\/jats:italic>\n <\/jats:styled-content>\n infection complicating bronchiectasis. After\n \n P. aeruginosa<\/jats:italic>\n <\/jats:styled-content>\n acquired resistance to quinolones, outpatient treatment became difficult, and the patient experienced repeated exacerbations and hospitalisations. Ceftazidime was effective; however, the patient could not be discharged because symptoms worsened immediately after its discontinuation. Initiating nebulised tobramycin for home use markedly improved symptoms and prevented subsequent exacerbation. Furthermore,\n \n P. aeruginosa<\/jats:italic>\n <\/jats:styled-content>\n isolated from sputum 1\u2009year after initiating nebulised tobramycin regained susceptibility to quinolones. This case suggests that nebulised tobramycin is a viable and effective option for long\u2010term management of chronic\n \n P. aeruginosa<\/jats:italic>\n <\/jats:styled-content>\n infection complicating bronchiectasis.\n <\/jats:p>","DOI":"10.1002\/rcr2.70558","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T02:00:21Z","timestamp":1773712821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Case of Effective Long\u2010Term Tobramycin Inhalation in a Patient With Bronchiectasis and Refractory\n Pseudomonas aeruginosa<\/i>\n Infection"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4202-7899","authenticated-orcid":false,"given":"Yasuaki","family":"Kotetsu","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maako","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Shiota","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyoshi","family":"Washio","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Ishimatsu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhito","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Moriwaki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Fukuoka National Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01126-2025"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901073400104"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.07.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2024.01.045"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh505"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70558","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:17:05Z","timestamp":1774585025000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/rcr2.70558"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70558","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2026-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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