{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:44:58Z","timestamp":1777452298829,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Methicillin\u2010resistant\n \n Staphylococcus aureus<\/jats:italic>\n <\/jats:styled-content>\n (MRSA) empyema remains challenging despite guideline\u2010based management. Gentian violet (GV), an antiseptic dye, has been sporadically used for MRSA infections but not systematically evaluated in pleural disease. We analysed nine consecutive patients with MRSA empyema treated with intrapleural GV irrigation following surgical debridement between 2011 and 2018. All patients successfully completed GV irrigation without procedural complications. Bacterial clearance was achieved within a median of 5\u2009days (IQR, 4\u20138), which was within the range observed in the non\u2010MRSA cohort treated with saline lavage (13\u2009days [IQR, 6\u201324]). No GV\u2010related adverse events occurred during a median follow\u2010up of 993\u2009days. Three patients developed\n \n Pseudomonas aeruginosa<\/jats:italic>\n <\/jats:styled-content>\n superinfection, likely reflecting GV's limited Gram\u2010negative activity. This case series demonstrates that intrapleural GV irrigation is feasible and safe, achieving microbiological clearance within an acceptable timeframe for MRSA empyema.\n <\/jats:p>","DOI":"10.1002\/rcr2.70562","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:42:05Z","timestamp":1774586525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrapleural Gentian Violet Irrigation for Refractory Methicillin\u2010Resistant\n \n Staphylococcus aureus<\/i>\n <\/scp>\n Empyema: A Case Series"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3534-1799","authenticated-orcid":false,"given":"Yasoo","family":"Sugiura","sequence":"first","affiliation":[{"name":"Department of General Thoracic Surgery National Hospital Organization, Kanagawa Hospital Hadano City Kanagawa 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