{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:59:48Z","timestamp":1780059588737,"version":"3.54.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Adverse drug reactions to first\u2010line antituberculosis (anti\u2010TB) therapy are common and may necessitate treatment interruption. While drug desensitization is increasingly used for delayed hypersensitivity, evidence supporting outpatient rapid oral desensitization in mild delayed reactions such as drug\u2010induced fever is limited. We report a 63\u2010year\u2010old man with active pulmonary tuberculosis who developed drug\u2010induced fever after commencing standard anti\u2010TB therapy. Sequential and additive drug challenge identified rifampicin as the offending agent. The patient subsequently underwent successful rapid oral rifampicin desensitization in an outpatient setting, enabling completion of 6 months of therapy without recurrence of adverse effects. This case demonstrates the feasibility of outpatient rapid oral desensitization for mild delayed hypersensitivity reactions, including drug\u2010induced fever. Such an approach may reduce treatment interruption and hospitalisation, particularly in settings where standardised outpatient desensitization protocols are lacking. Further studies are needed to define optimal strategies for managing mild delayed hypersensitivity reactions to anti\u2010TB medications.<\/jats:p>","DOI":"10.1002\/rcr2.70584","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:39:58Z","timestamp":1777628398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful Sequential and Additive Drug Challenge With Rapid Oral Desensitization in Rifampicin\u2010Induced Fever"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0999-7508","authenticated-orcid":false,"given":"Xin Yue","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Prince of Wales Hospital  Randwick New South Wales Australia"},{"name":"School of Medicine and Health UNSW  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine","family":"Zois","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Prince of Wales Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina61050911"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12161"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2014.4.3.156"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2024.142187"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.12.017"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.01.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/20009666.2018.1545516"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4168\/aard.2016.4.3.212"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3590"},{"key":"e_1_2_9_11_1","first-page":"697","article-title":"Desensitization Therapy of Anti\u2010Tuberculous Drugs","volume":"72","author":"Japanese Society of Tuberculosis","year":"1997","journal-title":"Kekkaku"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20104362.2001.01173\u20107.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.8118654"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.6.1518"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.20473\/jr.v7\u2010I.2.2021.79\u201085"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2021.438"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70584","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70584","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:29:07Z","timestamp":1779935347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/rcr2.70584"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70584","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70584"}}