{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:57:20Z","timestamp":1780059440652,"version":"3.54.0"},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This report describes the first documented case of brigatinib\u2010induced pleuritis in a patient with ALK\u2010positive non\u2010small cell lung cancer. A 77\u2010year\u2010old woman developed dyspnoea, fever, elevated inflammatory markers, and bilateral pleural effusion shortly after starting brigatinib as third\u2010line therapy. Pleural fluid analysis showed lymphocyte\u2010predominant exudative effusion without evidence of malignancy or infection, suggesting drug\u2010induced pleuritis. Discontinuation of brigatinib led to rapid clinical and radiographic improvement. Although disease progression later occurred, pleuritis did not recur. Re\u2010administration of brigatinib at a reduced dose of 30\u2009mg\/day achieved tumour shrinkage without pleuritis recurrence, and subsequent dose escalation to 60\u2009mg\/day was also tolerated. This case highlights that clinicians should consider drug\u2010induced pleuritis when pleural effusion develops during brigatinib therapy, particularly when it is inconsistent with the disease progression. Dose reduction to as low as 30\u2009mg\/day may be a safe and effective therapeutic option for selected patients.<\/jats:p>","DOI":"10.1002\/rcr2.70598","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:41:22Z","timestamp":1777941682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pleuritis Induced by Brigatinib During the Treatment of Non\u2010Small Cell Lung Cancer"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9402-9235","authenticated-orcid":false,"given":"Shohei","family":"Yano","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Hee","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Harima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1810171"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0026\u20102016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(16)30392\u20108"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.04.028"},{"key":"e_1_2_9_6_1","volume-title":"Alunbrig (brigatinib) Prescribing Information","author":"U.S. Food and Drug Administration","year":"2022"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272\u20105231(03)00125\u20104"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000518081"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70598","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70598","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:29:24Z","timestamp":1779935364000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/rcr2.70598"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70598","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70598"}}