{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T03:03:19Z","timestamp":1779937399674,"version":"3.53.1"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diffuse alveolar haemorrhage (DAH) is a rare but potentially life\u2010threatening syndrome with diverse etiologies. Human metapneumovirus (hMPV) infection has rarely been reported as a cause of DAH. We report two cases of DAH associated with hMPV infection in immunocompetent adults. In both patients, bronchoalveolar lavage fluid (BALF) showed progressively haemorrhagic returns and hemosiderin\u2010laden macrophages, consistent with DAH. Multiplex polymerase chain reaction (PCR) using BALF detected hMPV, while extensive investigations excluded autoimmune, bacterial, and other viral causes. These cases suggest that lower respiratory tract infection with hMPV can be associated with DAH, even in immunocompetent adults. Screening for hMPV should be considered in cases of DAH of unknown aetiology, and multiplex PCR using BALF is a useful diagnostic tool.<\/jats:p>","DOI":"10.1002\/rcr2.70599","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:56:50Z","timestamp":1777445810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two Cases of Diffuse Alveolar Haemorrhage Attributable to Human Metapneumovirus Infection: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Masamichi","family":"Lee","sequence":"first","affiliation":[{"name":"Kobe City Medical Center West Hospital  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Takiguchi","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center West Hospital  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7183-7338","authenticated-orcid":false,"given":"Yuu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center West Hospital  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Tanimoto","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Kobe Institute of Health  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Kobe Institute of Health  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8636-5243","authenticated-orcid":false,"given":"Hiromi","family":"Tomioka","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center West Hospital  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.03.1394"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026047"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2084"},{"key":"e_1_2_9_5_1","first-page":"31","article-title":"Diffuse Alveolar Hemorrhage Secondary to Human Metapneumovirus Pulmonary Infection","volume":"105","author":"Anstett S.","year":"2022","journal-title":"R.I. Medical Journal"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-018-1005-8"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70599","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:29:19Z","timestamp":1779935359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/rcr2.70599"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70599","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"2026-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70599"}}