{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T03:03:21Z","timestamp":1779937401210,"version":"3.53.1"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A 74\u2010year\u2010old man presented with abdominal pain. Preoperative evaluation for small bowel perforation revealed a 74\u2010mm tumour shadow obstructing the right lower lobe bronchus. Endobronchial biopsy from the truncus intermedius was diagnostic of squamous cell carcinoma (SCC). Pathological findings in the small intestine were consistent with SCC. Based on other radiological findings, the patient was diagnosed with stage IVB (cT4N3M1c) lung SCC (LUSC). Serum amylase levels were elevated at 1693\u2009U\/L (pancreatic amylase 184\u2009U\/L) prior to treatment. AMY1 (2D4) immunohistochemistry was positive, confirming amylase\u2010producing LUSC, a rarely reported entity. Amylase levels decreased to 203\u2009U\/L following combination therapy with carboplatin, nab\u2010paclitaxel and pembrolizumab. The patient had no symptoms or signs of pancreatic or salivary gland disease. To our knowledge, this is the first reported case of LUSC with both histological evidence of amylase production and hyperamylasemia. This case provides new evidence that LUSC can produce amylase and cause hyperamylasemia.<\/jats:p>","DOI":"10.1002\/rcr2.70609","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:39:36Z","timestamp":1778027976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Anti\u2010\n                    <scp>AMY1<\/scp>\n                    \u2010Positive Lung Squamous Cell Carcinoma With Severe Hyperamylasemia Linked to Disease Progression"],"prefix":"10.1002","volume":"14","author":[{"given":"Yusuke","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Tsukada","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Yazawa","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Nakazato","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology International University of Health and Welfare Hospital  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yokose","family":"Tomoyuki","sequence":"additional","affiliation":[{"name":"Department of Pathology Kanagawa Cancer Center  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2804-4588","authenticated-orcid":false,"given":"Kazuyuki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Dokkyo Medical University School of Medicine  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Tochigi Japan"},{"name":"Respiratory Endoscopy Center Dokkyo Medical University Hospital  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9480-5923","authenticated-orcid":false,"given":"Seiji","family":"Niho","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Clinical Immunology Dokkyo Medical University School of Medicine  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/21.11.1057"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.94.07050941"},{"issue":"11","key":"e_1_2_10_4_1","first-page":"3292","article-title":"Expression of Alpha\u2010Amylase in Human Lung Cancers","volume":"48","author":"Tomita N.","year":"1988","journal-title":"Cancer Research"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01372559"},{"issue":"3","key":"e_1_2_10_6_1","first-page":"246","article-title":"Genetic Analysis of Amylase\u2010Producing Cell Lines: Ectopic Activation of the Amylase Gene by Translocation","volume":"20","author":"Hata H.","year":"1990","journal-title":"Japanese Journal of Clinical Oncology"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70609","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:29:34Z","timestamp":1779935374000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/rcr2.70609"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70609","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70609"}}