{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:58:40Z","timestamp":1785383920447,"version":"3.55.0"},"reference-count":8,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Bronchopleural fistula (BPF) is a rare but potentially life\u2010threatening complication after pulmonary resection. When associated with Aspergillus infection, management becomes particularly challenging because of tissue necrosis and impaired bronchial healing. Although surgical intervention is generally recommended, optimal management of delayed\u2010onset fungal BPF remains controversial. We report two cases of postoperative\n \n Aspergillus fumigatus<\/jats:italic>\n <\/jats:styled-content>\n \u2013associated BPF following lung cancer surgery that were managed primarily with antifungal therapy and pleural drainage. In the first case, a delayed\u2010onset BPF developed 14\u2009months after bilobectomy and resolved completely with percutaneous drainage and prolonged voriconazole therapy without additional surgery. In the second case, limited surgical closure failed to eliminate persistent air leakage; however, subsequent antifungal therapy combined with continued drainage resulted in complete fistula closure. These cases suggest that in carefully selected patients with localized, delayed\u2010onset fungal BPF and clinical stability, antifungal\u2010based conservative management may be considered in carefully selected patients as a potential adjunct or alternative to aggressive surgical intervention. Careful patient selection and multidisciplinary evaluation are essential.\n <\/jats:p>","DOI":"10.1002\/rcr2.70635","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:37:42Z","timestamp":1783053462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antifungal\u2010Based Conservative Management of Delayed\u2010Onset Fungal Bronchopleural Fistula After Lung Cancer Surgery"],"prefix":"10.1002","volume":"14","author":[{"given":"Jonggeun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Thoracic & Cardiovascular Surgery, School of Medicine Pusan National University, Biomedical Research Institute, Pusan National University Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Seong","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Thoracic & Cardiovascular Surgery, School of Medicine Pusan National University, Biomedical Research Institute, Pusan National University Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Su","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Thoracic & Cardiovascular Surgery, School of Medicine Pusan National University, Biomedical Research Institute, Pusan National University Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/shc-23-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.03.102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03852-23"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2014.07.006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016228"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.08.136"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020191"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2022.10.005"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70635","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70635","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:06:20Z","timestamp":1785380780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":8,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/rcr2.70635"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70635","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70635"}}