{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:58:58Z","timestamp":1785383938241,"version":"3.55.0"},"reference-count":7,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tumour lysis syndrome (TLS) in solid tumours is rare but may occur in small\u2010cell lung cancer (SCLC) with a high tumour burden. We report a case of fatal TLS following tarlatamab treatment for relapsed SCLC. A 61\u2010year\u2010old woman with limited\u2010stage SCLC developed recurrence with extensive liver metastases after chemoradiotherapy and durvalumab consolidation therapy. Owing to rapid disease progression, an initial 1\u2010mg step\u2010up dose of tarlatamab was administered as second\u2010line treatment. On Day 2, the patient developed mild cytokine release syndrome, which improved with dexamethasone. On Day 6, she suddenly developed respiratory failure and impaired consciousness. Laboratory findings, including elevated lactate dehydrogenase, potassium, phosphorus and uric acid levels with acute kidney injury, suggested TLS and she died later that day. This case demonstrates that tarlatamab can induce fatal TLS even after a single 1\u2010mg dose. Patients with SCLC with extensive liver metastases require careful monitoring and aggressive strategies for TLS prevention.<\/jats:p>","DOI":"10.1002\/rcr2.70667","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T23:21:27Z","timestamp":1782688887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Initial Dose Tarlatamab\u2013Associated Tumour Lysis Syndrome in Small Cell Lung Cancer: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Katsuhiko","family":"Shibata","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Sano Kosei General Hospital  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5299-3978","authenticated-orcid":false,"given":"Hiromu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Sano Kosei General Hospital  Tochigi 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