{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:58:55Z","timestamp":1785383935687,"version":"3.55.0"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJAX242F"],"award-info":[{"award-number":["JPMJAX242F"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Immune checkpoint inhibitor (ICI) rechallenge may benefit selected patients with NSCLC, but the role of local radiotherapy for oligoprogression and late same\u2010agent rechallenge remains uncertain. We report a patient with Stage IVA lung adenocarcinoma and a programmed death\u2010ligand 1 tumour proportion score of \u2265\u200975% who achieved a durable partial response to first\u2010line pembrolizumab. After isolated left supraclavicular nodal oligoprogression in 2020, he received salvage radiotherapy and remained off systemic treatment for almost 5\u2009years. In late 2025, multiple new right lower lobe nodules and pleural\u2010based lesions appeared near the original primary site and enlarged on serial CT, prompting pembrolizumab rechallenge. CT in February 2026 showed a renewed partial response. This case suggests that rechallenge with pembrolizumab may remain reasonable at late relapse in carefully selected patients with durable initial benefit, limited progression controlled locally, a long treatment\u2010free interval, and good performance status.<\/jats:p>","DOI":"10.1002\/rcr2.70674","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:32:20Z","timestamp":1784082740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Renewed Response to Pembrolizumab After Salvage Radiotherapy for Oligoprogression in Advanced\n                    <scp>NSCLC<\/scp>\n                    : A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4280-3074","authenticated-orcid":false,"given":"Takayuki","family":"Niitsu","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Osaka General Medical Center  Osaka 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