{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:58:29Z","timestamp":1785383909997,"version":"3.55.0"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diffuse panbronchiolitis (DPB) is a chronic inflammatory lung disease of unknown aetiology predominantly affecting middle\u2010aged adults, characterized by chronic sinusitis, productive cough and exertional dyspnea. DPB is rare in children, and its clinical course remains poorly understood. We report a case of DPB in a 13\u2010year\u2010old girl in whom breath sounds were recorded throughout the treatment course using an electronic stethoscope. The patient was treated with low\u2010dose macrolide therapy, which led to improvement in clinical symptoms and pulmonary function, accompanied by parallel changes in abnormal breath sounds. Breath sound analysis revealed that coarse crackles resolved first, followed by sequential amelioration of adventitious continuous sounds from the peripheral to the central airways. Furthermore, a treatment duration of at least 6\u2009months was suggested to be necessary. Breath sound analysis may provide objective information regarding respiratory function and contribute to a deeper understanding of the pathophysiology of this rare disease.<\/jats:p>","DOI":"10.1002\/rcr2.70685","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:12:41Z","timestamp":1785201161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Breath Sound Changes During Erythromycin Therapy in Paediatric Diffuse Panbronchiolitis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0650-2397","authenticated-orcid":false,"given":"Katsuhito","family":"Iikura","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Jikei University School of Medicine  Tokyo Japan"},{"name":"Department of Pediatrics National Hospital Organization Nishisaitama\u2010Chuo National Hospital  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideshi","family":"Fujinaga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Nishisaitama\u2010Chuo National Hospital  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Tokoro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Nishisaitama\u2010Chuo National Hospital  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Koinuma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Nishisaitama\u2010Chuo National Hospital  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Nishisaitama\u2010Chuo National Hospital  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2620-0470","authenticated-orcid":false,"given":"Shinji","family":"Oana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Nishisaitama\u2010Chuo National Hospital  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00131805"},{"key":"e_1_2_10_3_1","first-page":"109","volume-title":"Annual Report on the Study of Diffuse Lung Disease in 1998","author":"Nakata K.","year":"1999"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.9710075"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2020.02.007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.160831"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70685","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70685","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:05:18Z","timestamp":1785380718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/rcr2.70685"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70685","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70685"}}