{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:24:58Z","timestamp":1787495098988,"version":"build-2736575974"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chylothorax is an uncommon presentation of mediastinal lymphoma, typically attributed to direct tumour invasion. This case illustrates a rare mechanism of superior vena cava (SVC) thrombosis and venolymphatic hypertension, leading to refractory chylothorax. A 33\u2010year\u2010old man with primary mediastinal large B\u2010cell lymphoma presented with dyspnoea and right\u2010sided pleural effusion. He was diagnosed with chylothorax. Lymphangiography revealed lymphatic leak secondary to thrombosis involving the venolymphatic junction. Despite conservative management including repeated thoracentesis, talc pleurodesis, total parenteral nutrition and anticoagulation, the chyle leak persisted. Mechanical thrombectomy was performed, successfully restoring flow in the brachiocephalic veins and SVC. The chylothorax resolved completely afterwards, allowing the chest drain to be removed. This case highlights venous thrombosis as a possible cause of refractory chylothorax. When systemic anticoagulation fails, mechanical thrombectomy is a definitive, causality\u2010driven treatment.<\/jats:p>","DOI":"10.1002\/rcr2.70688","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:58:10Z","timestamp":1784167090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Refractory Chylothorax in Primary Mediastinal Large B\u2010Cell Lymphoma: A Case of Superior Vena Cava Obstruction Thrombosis\u2010Induced Lymphatic Leak Salvaged by Mechanical Thrombectomy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-2646","authenticated-orcid":false,"given":"Yueming","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Medicine &amp; Therapeutics Prince of Wales Hospital  Hong Kong SAR China"},{"name":"Department of Respiratory and Critical Care Medicine The First People's Hospital of Foshan  Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anselm Wang Hei","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Imaging and Interventional Radiology Prince of Wales Hospital  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8454-0087","authenticated-orcid":false,"given":"Fanny Wai San","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Medicine &amp; Therapeutics Prince of Wales Hospital  Hong Kong SAR China"},{"name":"Department of Medicine &amp; Therapeutics The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-5846","authenticated-orcid":false,"given":"Ken Ka Pang","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine &amp; Therapeutics Prince of Wales Hospital  Hong Kong SAR China"},{"name":"Department of Medicine &amp; Therapeutics The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2025.102898"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.221"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2021.07.026"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-023-03775-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000966"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70688","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70688","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:05:06Z","timestamp":1785380706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/rcr2.70688"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70688","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70688"}}