{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:58:56Z","timestamp":1785383936419,"version":"3.55.0"},"reference-count":2,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report a case of selpercatinib\u2010induced deep skin fissures in a patient with RET fusion\u2010positive lung adenocarcinoma. Minor mechanical abrasions triggered severe fingertip fissures, which were likely exacerbated by selpercatinib\u2010related VEGF receptor inhibition. The condition improved with drug withdrawal and corticosteroids administration, enabling the continuation of treatment with careful management of recurrent episodes.<\/jats:p>","DOI":"10.1002\/rcr2.70689","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:51:22Z","timestamp":1784166682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selpercatinib\u2010Induced Deep Skin Fissures Triggered by Mechanical Friction in a Patient With\n                    <scp>RET<\/scp>\n                    Fusion\u2010Positive Lung Adenocarcinoma"],"prefix":"10.1002","volume":"14","author":[{"given":"Tomoyuki","family":"Ikeuchi","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization (NHO) Yonago Medical Center  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization (NHO) Yonago Medical Center  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Toge","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization (NHO) Yonago Medical Center  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Brioka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization (NHO) Yonago Medical Center  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine Tottori University  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309457"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2025.100792"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70689","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70689","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:07:47Z","timestamp":1785380867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":2,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/rcr2.70689"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70689","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70689"}}