{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:00:38Z","timestamp":1790301638308,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Organising pneumonia is an increasingly recognised pulmonary manifestation of ulcerative colitis, though nearly all reported cases are attributed to drug\u2010induced aetiology. The 2025 ERS\/ATS classification of interstitial pneumonias now explicitly lists ulcerative colitis among secondary causes of cicatricial organising pneumonia, formally recognising a disease\u2010intrinsic mechanism for organising pneumonia in ulcerative colitis. We present a 76\u2010year\u2010old woman with 10\u2010year ulcerative colitis pancolitis on stable mesalamine in biochemical remission (faecal calprotectin 62\u2009\u03bcg\/g, below the 80\u2009\u03bcg\/g histological activity threshold) who developed progressive dyspnea. Drug\u2010induced aetiology was systematically excluded: mesalamine had been stable for 10\u2009years, discontinuation produced no improvement, and corticosteroids were required for response. Transbronchial cryobiopsy was initially interpreted as fibrotic non\u2010specific interstitial pneumonia; expert pathology consultation revised the diagnosis to organising pneumonia with Masson bodies, changing management from antifibrotics to corticosteroids, illustrating the clinical consequences of cryobiopsy diagnostic discordance. Bronchoalveolar lavage revealed a neutrophil\u2010predominant profile (42% neutrophils, 3% lymphocytes), atypical for cryptogenic organising pneumonia, which typically shows lymphocytic predominance. This pattern may reflect gut\u2010lung axis immune trafficking in secondary organising pneumonia associated with ulcerative colitis. Concurrent seronegative arthritis was reclassified as ulcerative colitis\u2010associated spondyloarthropathy, removing rheumatoid arthritis\u2010associated interstitial lung disease from the differential. This case extends the sole prior report of organising pneumonia during confirmed ulcerative colitis remission by incorporating biomarker\u2010confirmed remission, systematic drug exclusion, cryobiopsy discordance with treatment\u2010altering consequences and contextualisation within the updated 2025 ERS\/ATS classification framework.<\/jats:p>","DOI":"10.1002\/rcr2.70702","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:18:02Z","timestamp":1788934682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disease\u2010Intrinsic Organising Pneumonia During Biomarker\u2010Confirmed Ulcerative Colitis Remission"],"prefix":"10.1002","volume":"14","author":[{"given":"Rahaf A.","family":"Jereisat","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Houston\/HCA\u2010Clear Lake  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7266-0364","authenticated-orcid":false,"given":"Nawras","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Houston\/HCA\u2010Clear Lake  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maher","family":"Dahdel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Houston\/HCA\u2010Clear Lake  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.07.042"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.05.037"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00158-2025"},{"issue":"2","key":"e_1_2_8_5_1","first-page":"E71","article-title":"Organizing Pneumonia Presenting After Ulcerative Colitis Remission","volume":"5","author":"Jang E. C.","year":"2013","journal-title":"Journal of Thoracic Disease"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaf008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-11-200706050-00008"},{"issue":"2","key":"e_1_2_8_8_1","first-page":"202","article-title":"Importance of the Dense Fine Speckled Pattern on HEp\u20102 Cells and Anti\u2010DFS70 Antibodies for the Diagnosis of Systemic Autoimmune Diseases","volume":"52","author":"Mahler M.","year":"2017","journal-title":"Clinical Reviews in Allergy & Immunology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199372030-00003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2116777"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002424"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202209-1812OC"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01707-z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0324230"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.03.016"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1125260"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70702","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:55:15Z","timestamp":1790301315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/rcr2.70702"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70702","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70702"}}