{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:18:18Z","timestamp":1787804298285,"version":"build-2784847793"},"reference-count":5,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Airway chondronecrosis is a rare but serious manifestation of late radiation\u2010induced toxicity. We report the case of a 67\u2010year\u2010old woman with epidermal growth factor receptor mutation\u2010positive lung adenocarcinoma who developed bronchial chondronecrosis 8\u2009years after proton\u2010beam therapy (PBT) to the right upper lobe nodule. For 2\u2009years, she was treated for cough\u2010variant asthma owing to a persistent cough. Chest computed tomography (CT) showed only a subtle irregularity of the right main bronchial wall. Bronchoscopy revealed yellow necrotic deposits in the right main bronchi. Although a conventional forceps biopsy was nondiagnostic, transbronchial lung cryobiopsy (TBLC) obtained cartilage specimens, confirming bronchial chondronecrosis without malignancy. Hyperbaric oxygen therapy (HBOT) (90 sessions in total) led to symptomatic and bronchoscopic improvement. This case highlights that very\u2010late\u2010onset airway chondronecrosis following PBT must be considered, even with minimal CT findings. TBLC is a valuable tool for diagnosing submucosal lesions and HBOT appears to be an effective therapy.<\/jats:p>","DOI":"10.1002\/rcr2.70705","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:38:27Z","timestamp":1786541907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bronchial Chondronecrosis After Proton Beam Therapy Successfully Treated With Hyperbaric Oxygen Therapy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6569-2023","authenticated-orcid":false,"given":"Masataka","family":"Hirai","sequence":"first","affiliation":[{"name":"Respiratory Disease Center Medical Research Institute KITANO HOSPITAL  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7251-659X","authenticated-orcid":false,"given":"Takamasa","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Medical Research Institute KITANO HOSPITAL  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9882-9620","authenticated-orcid":false,"given":"SungChul","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Kobe Proton Center  Kobe Japan"},{"name":"Radiation Toxicity Clinic Jutokukai Uegahara Hospital  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehisa","family":"Takagi","sequence":"additional","affiliation":[{"name":"Division of Therapeutic Radiology and Oncology Medical Research Institute KITANO HOSPITAL  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Honda","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Medical Research Institute KITANO HOSPITAL  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yokiko","family":"Ohe","sequence":"additional","affiliation":[{"name":"Radiation Toxicity Clinic Jutokukai Uegahara Hospital  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9923-3266","authenticated-orcid":false,"given":"Daiki","family":"Inoue","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Medical Research Institute KITANO HOSPITAL  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7584-4839","authenticated-orcid":false,"given":"Motonari","family":"Fukui","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Medical Research Institute KITANO HOSPITAL  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0524-0508","authenticated-orcid":false,"given":"Satoshi","family":"Marumo","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center Medical Research Institute KITANO HOSPITAL  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","first-page":"273","article-title":"Radiation\u2010Associated Airway Necrosis","volume":"13","author":"Alraiyes A. H.","year":"2013","journal-title":"Ochsner Journal"},{"issue":"4","key":"e_1_2_10_3_1","first-page":"205","article-title":"Radionecrosis of the Larynx: Case Report and Review of the Literature","volume":"30","author":"Cukurova I.","year":"2010","journal-title":"Acta Otorhinolaryngologica Italica"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1970"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr\u201020\u2010552"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900605"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70705","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:23:57Z","timestamp":1787801037000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":5,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/rcr2.70705"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70705","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70705"}}