{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:00:45Z","timestamp":1790301645261,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Non\u2010invasive ventilation (NIV) is standard respiratory support for amyotrophic lateral sclerosis (ALS), but intolerance may limit its use. High\u2010flow nasal cannula (HFNC) has emerged as a potential alternative in selected patients, but evidence regarding its use remains scarce. We describe 18 ALS patients' management with HFNC between 2014 and 2024 after documented intolerance to NIV. Mean age at HFNC initiation was 65.1\u2009\u00b1\u200912.5\u2009years, and 66.7% of patients were female. Partial NIV intolerance occurred in 38.9% of cases, while 33.3% tolerated intermittent combined NIV and HFNC. During follow\u2010up, 50.0% of patients required hospitalization, 33.3% experienced respiratory infections, and 27.8% died. Arterial blood gas parameters remained stable, including PaCO\n                    <jats:sub>2<\/jats:sub>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.314). Functional status declined significantly, with Barthel Index decreasing (35.0\u2009\u00b1\u200920.5 vs. 11.7\u2009\u00b1\u200911.3;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), whereas respiratory muscle strength remained unchanged. HFNC was feasible as home\u2010based support in ALS patients intolerant to NIV, warranting prospective comparative evaluation.\n                  <\/jats:p>","DOI":"10.1002\/rcr2.70744","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:46:04Z","timestamp":1787967964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of High\u2010Flow Nasal Cannula in Amyotrophic Lateral Sclerosis Patients Intolerant to Non\u2010Invasive Ventilation: A Case Series"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4000-6007","authenticated-orcid":false,"given":"Fabio","family":"Varon\u2010Vega","sequence":"first","affiliation":[{"name":"Critical Care Service Fundaci\u00f3n Cardioinfantil\u2010Instituto de Cardiolog\u00eda  Bogot\u00e1 Colombia"},{"name":"Critical Care and Lung Transplantation Service Fundaci\u00f3n Neumol\u00f3gica Colombiana  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Evelio","family":"Franco Parra","sequence":"additional","affiliation":[{"name":"Sistemas de terapia respiratoria, STR en Casa  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris Fabiola","family":"Adame Ochoa","sequence":"additional","affiliation":[{"name":"Sistemas de terapia respiratoria, STR en Casa  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Uricoechea","sequence":"additional","affiliation":[{"name":"Universidad Manuela Beltan  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-2238","authenticated-orcid":false,"given":"Eduardo","family":"Tuta\u2010Quintero","sequence":"additional","affiliation":[{"name":"School of Medicine Universidad de la Sabana  Chia Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8275-4399","authenticated-orcid":false,"given":"Mar\u00eda Camila","family":"Martinez Ayala","sequence":"additional","affiliation":[{"name":"Critical Care Service Fundaci\u00f3n Cardioinfantil\u2010Instituto de Cardiolog\u00eda  Bogot\u00e1 Colombia"},{"name":"School of Medicine Universidad de la Sabana  Chia Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.71"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-98817-9.00031-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2023.06.029"},{"issue":"10","key":"e_1_2_10_5_1","article-title":"Mechanical Ventilation for Amyotrophic Lateral Sclerosis\/Motor Neuron Disease","volume":"10","author":"Radunovic 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