{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:56:46Z","timestamp":1791266206661,"version":"4.1.0"},"reference-count":4,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chronic lymphocytic leukaemia (CLL) is characterised by profound immune dysfunction, increasing susceptibility to severe and persistent infections such as COVID\u201019. Our case report presents a 69\u2010year\u2010old woman with CLL who exhibited a prolonged duration of SARS\u2010CoV\u20102 RT\u2010PCR positivity\u2014127\u2009days\u2014despite receiving standard therapies including dexamethasone and remdesivir. The patient, previously on maintenance ibrutinib, presented with fever and ground\u2010glass opacities on CT scan and laboratory findings revealed marked lymphocytosis, elevated inflammatory markers and hepatic and renal dysfunction. Persistent viral shedding was attributed to CLL\u2010associated hypogammaglobulinemia and chemotherapy\u2010induced immunosuppression, resulting in impaired antibody response and eventual fatal hypoxemia. This case underscores the challenges of managing COVID\u201019 in CLL patients and highlights the need for individualised treatment strategies, including consideration of monoclonal antibodies and immunoglobulin replacement, to address prolonged viral replication and improve clinical outcomes in this vulnerable population.<\/jats:p>","DOI":"10.1002\/rcr2.70767","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:42:10Z","timestamp":1791265330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Persistent\n                    <scp>SARS<\/scp>\n                    \u2010\n                    <scp>CoV<\/scp>\n                    \u20102\n                    <scp>RNA<\/scp>\n                    Positivity in a Chronic Lymphocytic Leukaemia Patient for 127\u2009Days After Disease Onset: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6290-7693","authenticated-orcid":false,"given":"Farnoosh","family":"Khamseh","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Tropical Medicine, Imam Hossein Hospital, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir\u2010Hossein","family":"Moghtader\u2010Mojdehi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Tropical Medicine, Imam Hossein Hospital, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Nemati","sequence":"additional","affiliation":[{"name":"Department of Critical Care Nursing, School of Nursing and Midwifery Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Haghighi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Tropical Medicine, Imam Hossein Hospital, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1186\/s12879-024-09794-z","article-title":"A Case Report of Prolonged Viral Shedding of SARS\u2010CoV\u20102 in a Patient Who Receive Ibrutinib for CLL Therapy","volume":"24","author":"Ma S.","year":"2024","journal-title":"BMC Infectious Diseases"},{"issue":"7","key":"e_1_2_10_3_1","article-title":"A Case of Chronic Lymphocytic Leukemia Coinciding With COVID\u201019","volume":"15","author":"Jeraiby M. A.","year":"2023","journal-title":"Cureus"},{"issue":"1","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000534540","article-title":"COVID\u201019 in Patients With Chronic Lymphocytic Leukemia: What Have we Learned?","volume":"147","author":"Harel R.","year":"2024","journal-title":"Acta Haematologica"},{"issue":"1","key":"e_1_2_10_5_1","article-title":"Long\u2010Lasting SARS\u2010CoV\u20102 Infection With Post\u2010COVID\u201019 Chronic Interstitial Pneumonia in a Patient With Chronic Lymphocytic Leukemia Treated Successfully With Intravenous Immunoglobulin","volume":"16","author":"Haddad A.","year":"2024","journal-title":"Cureus"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70767","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70767","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:42:12Z","timestamp":1791265332000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":4,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/rcr2.70767"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70767","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70767"}}