{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:52:07Z","timestamp":1791337927476,"version":"4.3.1"},"reference-count":5,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pulmonary involvement in transthyretin amyloidosis (ATTR) is rare, and tracheobronchial involvement is particularly uncommon. We report a case of wild\u2010type ATTR amyloidosis presenting with hemoptysis in a 66\u2010year\u2010old woman with dyspnea. Chest computed tomography revealed bronchial wall thickening and infiltrative opacities. Bronchoscopy showed irregular mucosal lesions extending from the trachea to both bronchi. Histopathological examination of bronchial biopsy specimens showed Congo red\u2010positive deposits, and immunohistochemistry confirmed transthyretin, establishing the diagnosis of ATTR amyloidosis. Systemic evaluation and genetic testing excluded systemic and hereditary disease, leading to a diagnosis of localized wild\u2010type ATTR. Bronchial aspirate cultures yielded\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Mycobacterium mucogenicum<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and antifungal therapy was administered for a suspected concomitant airway infection. This rare presentation of tracheobronchial\u2010localized ATTR amyloidosis underscores the importance of considering amyloidosis in the differential diagnosis of hemoptysis and the diagnostic role of bronchoscopy.\n                  <\/jats:p>","DOI":"10.1002\/rcr2.70781","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:25:46Z","timestamp":1791336346000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Localized Tracheobronchial Transthyretin Amyloidosis Diagnosed After Hemoptysis: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Koichi","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Steel Memorial Muroran Hospital  Muroran Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5378-4701","authenticated-orcid":false,"given":"Yasumasa","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Steel Memorial Muroran Hospital  Muroran Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1851-4160","authenticated-orcid":false,"given":"Masahiro","family":"Yanagi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Steel Memorial Muroran Hospital  Muroran Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Michimata","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Steel Memorial Muroran Hospital  Muroran Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Nagahisa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Steel Memorial Muroran Hospital  Muroran Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Kondoh","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Steel Memorial Muroran Hospital  Muroran Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.5858\/arpa.2016-0102-RA","article-title":"Amyloidosis of the Lung","volume":"141","author":"Khoor A.","year":"2017","journal-title":"Archives of Pathology & Laboratory Medicine"},{"issue":"4","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1002\/rcr2.70171","article-title":"Tracheobronchial Amyloidosis: A Rare Airway Disorder With Diagnostic and Therapeutic Challenges: A Case Report and Literature Review","volume":"13","author":"Shterev F.","year":"2025","journal-title":"Respirology Case Reports"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2022.106761","article-title":"Clinical, Radiologic, and Pathologic Features and Outcomes of Pulmonary Transthyretin Amyloidosis","volume":"194","author":"Eggleston R. H.","year":"2022","journal-title":"Respiratory Medicine"},{"issue":"145","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0046-2017","article-title":"The Lung in Amyloidosis","volume":"26","author":"Milani P.","year":"2017","journal-title":"European Respiratory Review"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01813-2017","article-title":"Observational, Multicentre Study on the Epidemiology of Haemoptysis","volume":"51","author":"Mondoni M.","year":"2018","journal-title":"European Respiratory Journal"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70781","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:25:47Z","timestamp":1791336347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":5,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/rcr2.70781"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70781","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70781"}}