{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:38:47Z","timestamp":1792553927210,"version":"4.5.0"},"reference-count":7,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    EBUS\u2010guided trans\u2010bronchial mediastinal cryobiopsy (EBUS\u2010TBMC) improves diagnostic yield over EBUS\u2010TBNA but conventionally requires en\u2010bloc removal of bronchoscope and frozen specimen, risking loss of airway control and procedural inefficiency. Retrieval of cryobiopsy specimens through\u2010working channel (TWC) may address these limitations, but its feasibility and diagnostic adequacy are uncertain. Prospective evaluation was completed of 13 patients undergoing EBUS\u2010TBMC at a single centre (August 2025 to January 2026). A 1.1\u2009mm Erbe cryoprobe was advanced through an echobronchoscope with a 2.2\u2009mm working channel (\n                    <jats:italic>BF\u2010UC190F<\/jats:italic>\n                    , Olympus Medical, Japan) via needle tract formed via EBUS\u2010TBNA. Fourteen lymph node stations underwent paired en\u2010bloc and TWC biopsies. Paired biopsies were completed in 92.3% of targets. Median specimen size was equivalent (3\u2009mm each;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.197). Diagnostic yield was 93% (en\u2010bloc) versus 79% (TWC);\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.48; versus 46% (EBUS\u2010TBNA). There were no post procedural complications. TWC cryobiopsy using a 1.1\u2009mm probe through a standard 2.2\u2009mm working channel is feasible and safe compared to conventional\n                    <jats:italic>en\u2010bloc<\/jats:italic>\n                    cryobiopsy.\n                  <\/jats:p>","DOI":"10.1002\/rcr2.70784","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:04:37Z","timestamp":1791965077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective Case Series to Determine the Feasibility, Diagnostic Yield and Safety of Performing\n                    <scp>EBUS<\/scp>\n                    Guided Trans\u2010Bronchial Mediastinal Cryobiopsy (\n                    <scp>EBUS<\/scp>\n                    \u2010\n                    <scp>TBMC<\/scp>\n                    ) of Lymph Nodes Using 1.1\u2009mm Cryoprobe Through a Working Channel of Linear\n                    <scp>EBUS<\/scp>\n                    Bronchoscope Versus Conventional En\u2010Bloc Cryobiopsy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6988-5576","authenticated-orcid":false,"given":"Jolyn","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine St John of God Midland Public and Private Hospital  Midland Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0046-0870","authenticated-orcid":false,"given":"David","family":"Manners","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine St John of God Midland Public and Private Hospital  Midland Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"issue":"6","key":"e_1_2_9_2_1","first-page":"24","article-title":"Mediastinal Lymph Node Cryobiopsy Guided by Endobronchial Ultrasound: A Comprehensive Review of Methods and Outcomes","volume":"9","author":"Kamath S.","year":"2025","journal-title":"Media"},{"issue":"34","key":"e_1_2_9_3_1","first-page":"1","article-title":"Transbronchial Mediastinal Cryobiopsy\u2014Literature Review and Practice Recommendations","volume":"9","author":"Romero A. O.","year":"2024","journal-title":"AME Medical Journal"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.70082"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000004039"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-69702-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202401\u20100192ST"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00342-2026"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.70784","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:47:29Z","timestamp":1792550849000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/rcr2.70784"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70784","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70784"}}