{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:15:23Z","timestamp":1790612123681,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dasatinib is a potent and effective second\u2010generation oral tyrosine kinase inhibitor that is clinically indicated for the treatment of imatinib\u2010resistant or imatinib\u2010intolerant breakpoint cluster region\u2010Abelson (BCR\u2010ABL)\u2010positive chronic myeloid leukaemia (CML) or for Philadelphia chromosome\u2010positive acute lymphocytic leukaemia. The most common adverse events associated with dasatinib therapy are skin rash, gastrointestinal upset, pancytopenia, pulmonary hypertension, and fluid retention, including pleural effusion. However, chylothorax secondary to dasatinib administration has rarely been reported. Although the underlying mechanism leading to dasatinib\u2010induced chylothorax is uncertain, the preferred treatment options are usually supported with diuretics or systemic steroids. Moreover, the discontinuation of the drug is mandatory in refractory cases. Here, we present the case of a patient with dasatinib\u2010induced chylothorax, and review the previously reported cases in the literature.<\/jats:p>","DOI":"10.1002\/rcr2.753","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T17:02:29Z","timestamp":1620493349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dasatinib\u2010induced chylothorax in a patient with chronic myeloid leukaemia: a case report and literature review"],"prefix":"10.1002","volume":"9","author":[{"given":"Chao\u2010Chin","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui\u2010Feng","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6662-6522","authenticated-orcid":false,"given":"Kuan\u2010Li","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328338c486"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.2012.0196"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.191871"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2017.11929535"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-231653"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.11.005"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.4065\/80.7.867"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.3002-19"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01096-2017"},{"key":"e_1_2_4_11_1","first-page":"A3479","article-title":"Dasatinib induced chylothorax","volume":"195","author":"Trivedi PC","year":"2017","journal-title":"Am. 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