{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T06:02:45Z","timestamp":1770530565569,"version":"3.49.0"},"reference-count":6,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the clinical setting, it is often difficult to judge whether honeycomb\u2010like structures represent progression of fibrosis in pulmonary sarcoidosis or a complication by interstitial pneumonitis. This report described a valuable case in which pathology of video\u2010assisted thoracoscopic surgery specimens collected from the lungs with honeycomb\u2010like structures that were continuous with the dilated bronchioles on chest computed tomography (CT) showed granulomas in the membranous bronchiole walls, thereby demonstrating that the honeycomb\u2010like structures were lung lesions of sarcoidosis. Pathological features of these structures on chest CT included cystic changes attributable to incorporation of peripheral alveoli into dilated bronchioles in lobules: these findings in lung sarcoidosis were different from those corresponding to honeycomb lung in idiopathic pulmonary fibrosis\/usual interstitial pneumonia. Radiological and pathological findings showed the possibility that progressive clustering of dilated bronchi and bronchioles causes cystic changes, resulting in the formation of honeycomb\u2010like structures as fibrosis progresses in sarcoidosis with lung involvement.<\/jats:p>","DOI":"10.1002\/rcr2.782","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T16:12:22Z","timestamp":1621440742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Honeycomb\u2010like structures in sarcoidosis pathologically showing granulomas in walls of clustered bronchioles"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9220-3419","authenticated-orcid":false,"given":"Michiru","family":"Sawahata","sequence":"first","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine Jichi Medical University  Shimotsuke Japan"},{"name":"Department of Respiratory Medicine National Hospital Organization Utsunomiya National Hospital  Utsunomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamiko","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Pathology Kanagawa Cardiovascular and Respiratory Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kawanobe","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine JR Tokyo General Hospital  Shibuya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiyoko","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine JR Tokyo General Hospital  Shibuya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Shinjuku Tsurukame Clinic  Shibuya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.08.008"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.539"},{"key":"e_1_2_4_4_1","first-page":"69","article-title":"Five cases with sarcoidosis whose clinical features mimic interstitial pneumonia","volume":"19","author":"Shigematsu M","year":"1999","journal-title":"JSSOG"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182785a2d"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0615"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1255ST"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:06:13Z","timestamp":1693551973000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,19]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/rcr2.782"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.782","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,19]]},"assertion":[{"value":"2021-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00782"}}