{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:53:22Z","timestamp":1772891602078,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Durvalumab, an anti\u2010programmed cell death\u2010ligand 1 (PD\u2010L1) antibody, is currently used in the maintenance therapy for patients with stage III non\u2010small cell lung cancer after platinum\u2010based chemoradiotherapy. A 69\u2010year\u2010old male with lung adenocarcinoma, clinical stage IIIA, was treated with chemoradiotherapy. As the treatments progressed, his dry cough gradually subsided. After chemoradiotherapy had been completed, we started durvalumab administration. One month later, his dry cough relapsed and persisted. Based on the changes of his blood eosinophil counts, we clinically diagnosed him with asthma. A 71\u2010year\u2010old male with lung adenocarcinoma, clinical stage IIIB, was treated with chemoradiotherapy. After completing chemoradiotherapy, we initiated durvalumab administration. After 6\u00a0months, his dry cough was noticed to involve wheezing. Based on his spirometric values and the fraction of exhaled nitric oxide, a clinical diagnosis of asthma was established. Asthma should be considered as one of the possible side effects when immune checkpoint inhibitors are used in cancer treatment.<\/jats:p>","DOI":"10.1002\/rcr2.835","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T08:59:06Z","timestamp":1629363546000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Asthma caused by durvalumab after chemoradiotherapy in two patients with non\u2010small cell lung cancer"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6732-5625","authenticated-orcid":false,"given":"Takehiro","family":"Uemura","sequence":"first","affiliation":[{"name":"Department of Thoracic Oncology Aichi Cancer Center Hospital  Nagoya Japan"},{"name":"Department of Respiratory Medicine, Allergy and Clinical Immunology Nagoya City University Graduate School of Medical Sciences  Nagoya 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