{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:52Z","timestamp":1753870192593,"version":"3.41.2"},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T00:00:00Z","timestamp":1633219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunoglobulin G4 (IgG4)\u2010related disease is established as a new clinical entity, characterized by high levels of plasma IgG4 and IgG4\u2010positive plasma cell infiltration. However, the elevation of plasma IgG4 and infiltration of IgG4\u2010positive cells have been observed in other diseases, including malignancy. We experienced a case of prominent IgG4\u2010positive lymphadenopathy, which was diagnosed as a reactive lesion in response to lung cancer. The cancerous lesion was so small in size that it was difficult to reveal the coexisting lung cancer. Surgical lymph node biopsy and endobronchial ultrasound\u2010guided transbronchial needle aspiration did not reveal lymph node metastasis of cancer. Mediastinal lymph node dissection finally revealed it. After the right upper lobectomy, the patient underwent postoperative chemotherapy and remains cancer\u2010free after 1\u2009year. Our case suggests that close examination and careful follow\u2010up are necessary when IgG4\u2010positive lymphadenopathy is observed.<\/jats:p>","DOI":"10.1002\/rcr2.854","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T13:03:43Z","timestamp":1633439023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of prominent immunoglobulin <scp>G4<\/scp>\u2010positive lymphadenopathy in response to microscopic lung cancer"],"prefix":"10.1002","volume":"9","author":[{"given":"Motoi","family":"Yuzawa","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Saitama Medical Center Jichi Medical University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9893-0254","authenticated-orcid":false,"given":"Hiromitsu","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of 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