{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:53Z","timestamp":1753870193146,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multifocal micronodular pneumocyte hyperplasia (MMPH) is the lesser known pulmonary manifestation of tuberous sclerosis. It manifests radiologically as diffuse small ground\u2010glass and solid nodules. Accurate diagnosis is essential as it can be mistaken for miliary tuberculosis or malignant lesions which necessitates specific treatment. Constellation of radiological features such as multicentric disease at onset and stability over time can help to distinguish MMPH from its differentials. Histologically, MMPH is characterized by hamartomatous proliferation of type II pneumocytes with a lack of high nuclear to cytoplasmic ratio. MMPH confers a benign prognosis unlike its differentials. Therefore, accurate diagnosis is paramount in ensuring appropriate care is delivered. Here, we describe the radiological and histological features of MMPH in a patient with genetically proven tuberous sclerosis complex and co\u2010existing lymphangioleiomyomatosis.<\/jats:p>","DOI":"10.1002\/rcr2.870","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T08:44:33Z","timestamp":1635410673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent pneumothoraces with diffuse small ground\u2010glass and solid nodules"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3002-1489","authenticated-orcid":false,"given":"Li Yan Sandra","family":"Hui","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Changi General Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin Min","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Singapore General Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ing Xiang","family":"Soo","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery National Heart Centre  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Ying","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Singapore General Hospital  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