{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:56Z","timestamp":1753870196774,"version":"3.41.2"},"reference-count":4,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T00:00:00Z","timestamp":1644624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chylothorax is an uncommon disease entity, but it occasionally poses a diagnostic challenge to physicians. Pleural fluid triglyceride level has been advocated as a screening test to diagnose chylothorax. However, its level can be depressed if there is an additional pathology driving the process of pleural fluid production. We report a case of high\u2010volume pleural fluid output due to dual pathologies, cirrhotic hydrothorax and chylothorax, causing an initial failure to diagnose chylothorax due to low pleural fluid triglyceride level. The fluid triglyceride levels were unmasked after the treatment for underlying portal hypertension. These findings were further substantiated by positive lipoprotein electrophoresis for chylomicron. In this patient, lipoprotein electrophoresis of his pleural fluid specimen helps distinguish chylothorax as a second pathology amidst the underlying cirrhotic hydrothorax.<\/jats:p>","DOI":"10.1002\/rcr2.907","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T13:00:13Z","timestamp":1644670813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changing pleural fluid triglyceride levels in cirrhotic chylothorax"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-5846","authenticated-orcid":false,"given":"Ka Pang","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Medicine &amp; Therapeutics Prince of Wales Hospital  Hong Kong"},{"name":"Department of Medicine &amp; Therapeutics Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing Ho","family":"Yip","sequence":"additional","affiliation":[{"name":"Department of Medicine &amp; Therapeutics Prince of Wales Hospital  Hong Kong"},{"name":"Department of Medicine &amp; Therapeutics Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0795-1768","authenticated-orcid":false,"given":"Tina Yee Ching","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology Princess Margaret Hospital  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8714-4792","authenticated-orcid":false,"given":"Chun\u2010Yiu","family":"Law","sequence":"additional","affiliation":[{"name":"Division of Chemical Pathology, Department of Pathology Queen Mary Hospital  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,12]]},"reference":[{"issue":"62","key":"e_1_2_7_2_1","first-page":"558","article-title":"Cirrhosis\u2010related intrathoracic disease. Imaging features in 1038 patients","volume":"52","author":"Malagari K","year":"2005","journal-title":"Hepatogastroenterology"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1378\/chest.114.1.154"},{"issue":"11","key":"e_1_2_7_4_1","first-page":"700","article-title":"The lipoprotein profile of chylous and nonchylous pleural effusions","volume":"55","author":"Staats BA","year":"1980","journal-title":"Mayo Clin Proc"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1021\/pr5004856"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.907","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.907","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T17:22:43Z","timestamp":1693156963000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,12]]},"references-count":4,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/rcr2.907"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.907","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2022,2,12]]},"assertion":[{"value":"2021-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e0907"}}