{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:10:01Z","timestamp":1753870201673,"version":"3.41.2"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T00:00:00Z","timestamp":1648339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pulmonary Langerhans cell histiocytosis is a rare disease caused by the proliferation of CD1a\u2010positive histiocyte\u2010like cells infiltrating the lung's interstitial layer. Most cases affect young to middle\u2010aged persons, especially adult heavy cigarette smokers. A 49\u2010year\u2010old male heavy smoker (40 pack\u2010year), with non\u2010productive cough, dyspnoea and desaturation, presented with a right\u2010sided pneumothorax on chest x\u2010ray with total atelectasis. Chest computed tomography (CT) revealed bilateral multiple thick\u2010walled infiltrated cysts and multiple ground\u2010glass nodules throughout the entire lung. Surgery with minimal invasive thoracoscopic lung biopsy and pleurodesis was performed. Pathology showed histiocyte\u2010like cells aggregates in the pulmonary parenchyma. Immunohistochemical stain demonstrated CD1a(+), S100(+) and CD68(+). After 3\u2009months of smoking cessation, clear improvement was evidenced with a chest CT showing bilateral multiple thin\u2010walled rounded cysts and multiple ground\u2010glass nodules that are smaller in size and decreased in numbers. Early minimal invasive thoracoscopic lung biopsy and pleurodesis can also be a choice if the development of secondary spontaneous pneumothorax occurs.<\/jats:p>","DOI":"10.1002\/rcr2.939","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T05:52:59Z","timestamp":1648446779000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous pneumothorax with pulmonary Langerhans cell histiocytosis (<scp>PLCH<\/scp>) in an adult heavy cigarette smoker\u2014A case report"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-7627","authenticated-orcid":false,"given":"Chiao\u2010Yun","family":"Tsai","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Chung Shan Medical University Hospital  Taichung Taiwan, Republic of China"},{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsu\u2010Chih","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Chung Shan Medical University Hospital  Taichung Taiwan, Republic of China"},{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Dong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology Chung Shan Medical University Hospital  Taichung Taiwan, Republic of China"},{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiun\u2010Yi","family":"Hsia","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Chung Shan Medical University Hospital  Taichung Taiwan, Republic of China"},{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Chung Shan Medical University Hospital  Taichung Taiwan, Republic of China"},{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2201050"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.1.9906010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.5152"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.5.1452"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114782"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.6.7911710"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.3.1028"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.939","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.939","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T12:19:37Z","timestamp":1692965977000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,27]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/rcr2.939"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.939","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2022,3,27]]},"assertion":[{"value":"2022-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e0939"}}