{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:10:04Z","timestamp":1753870204096,"version":"3.41.2"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 71\u2010year\u2010old man, who was found to have a posterior mediastinal tumour, was referred to our hospital. Contrast\u2010enhanced computed tomography (CT) showed a 15\u2010cm soft tissue shadow in the posterior mediastinum, with many affected areas and a gradually increasing pattern. We also detected oligemic areas with poor contrast\u2010filling. There was no invasion into the adjacent vertebral body and the blood vessels penetrating the interior were intact. Positron emission tomography\u2013CT revealed a high maximum standardized uptake level of 4.53 in the mediastinal masses. We performed thoracoscopic surgery for the biopsy. Histological findings showed lymphoplasmacytic infiltration in the fibrous stroma as well as storiform fibrosis. Immunohistochemical examination revealed abundant infiltration of immunoglobulin G4 (IgG4)\u2010positive plasma cells and 40% IgG4\/IgG\u2010positive plasma cells. Postoperative serum examinations showed a high serum IgG4 level (570\u2009mg\/dl). Accordingly, we diagnosed the patient with IgG4\u2010related fibrosing mediastinitis, a rare manifestation of IgG4\u2010related disease.<\/jats:p>","DOI":"10.1002\/rcr2.958","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T03:40:47Z","timestamp":1652154047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>IgG4<\/scp>\u2010associated fibrosing mediastinitis requiring differentiation from posterior mediastinal tumour: A case report"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7428-9618","authenticated-orcid":false,"given":"Yoshimitsu","family":"Hirai","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuta","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9643-1475","authenticated-orcid":false,"given":"Hideto","family":"Iguchi","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Fusamoto","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Yata","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Wakayama Medical University  Wakayama 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