{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:10:04Z","timestamp":1753870204186,"version":"3.41.2"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2022,7]]},"abstract":"Abstract<\/jats:title>The coronavirus disease\u20102019 (COVID<\/jats:styled-content>\u201019) has spread worldwide. Previous studies indicated a low prevalence of COVID<\/jats:styled-content>\u201019 induced acute exacerbations of asthma. We present a 39\u2010year\u2010old\u2010male obese asthmatic case who experienced acute asthma exacerbation during COVID<\/jats:styled-content>\u201019. On day 8 of infection, his cough and dyspnea worsened with hypoxia and wheezing. Laboratory test results revealed elevated interleukin\u20106 (IL<\/jats:styled-content>\u20106) and total immunoglobulin E (IgE<\/jats:styled-content>) levels without eosinophilia. Two months since the onset, hypoxia disappeared with decreased IL<\/jats:styled-content>\u20106 and IgE<\/jats:styled-content> levels. Our case suggested that obesity and high serum IL<\/jats:styled-content>\u20106 and IgE<\/jats:styled-content> levels may have contributed to atypical asthma exacerbation in COVID<\/jats:styled-content>\u201019.<\/jats:p>","DOI":"10.1002\/rcr2.979","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T09:25:05Z","timestamp":1654593905000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case report of coronavirus disease\u20102019\u2010induced acute asthma exacerbation in an obese patient"],"prefix":"10.1002","volume":"10","author":[{"given":"Hisashi","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Japan Self\u2010Defense Forces Central Hospital Tokyo Japan"},{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3189-1702","authenticated-orcid":false,"given":"Jun","family":"Miyata","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Japan Self\u2010Defense Forces Central Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Japan Self\u2010Defense Forces Central Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Kawana","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"Asthma and COVID\u201019; different entities, same outcome: a meta\u2010analysis of 107,983 patients","volume":"59","author":"Hussein MH","year":"2021","journal-title":"J Asthma"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.06.032"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.05.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)30048-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.023"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.979","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T01:11:48Z","timestamp":1692839508000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,7]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/rcr2.979"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.979","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2022,6,7]]},"assertion":[{"value":"2021-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e0979"}}