{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:10:05Z","timestamp":1753870205043,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe the first case of antisynthetase syndrome (ASS) with antibodies to anti\u2010glycyl tRNA synthetase (EJ\u20101) with antiphospholipid syndrome (APLS). A 66\u2010year\u2010old man presented with progressive dyspnoea, fever, dry cough and proximal muscle weakness over several months on a background of cryptogenic organizing pneumonia. Examination revealed bibasal fine chest crackles, proximal muscle weakness of the upper and lower limbs, digital skin thickening and facial telangiectasias. Creatine kinase was elevated and autoimmune screening was positive for anti\u2010EJ\u20101, anti\u2010beta\u20102\u2010glycoprotein, anti\u2010Ro and anti\u2010La antibodies. Computed tomography of the chest revealed a usual interstitial pneumonia pattern and a ventilation\u2013perfusion scan demonstrated scintigraphic evidence of bilateral pulmonary emboli. A diagnosis of ASS and APLS was made. Immunosuppressive therapy including pulsed methylprednisolone, rituximab and mycophenolate was commenced with improvement in symptoms. This case highlights the importance of evaluation for ASS in idiopathic interstitial pneumonia, and APLS in ASS patients.<\/jats:p>","DOI":"10.1002\/rcr2.990","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T06:04:53Z","timestamp":1655186693000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antisynthetase syndrome with rare <scp>EJ<\/scp>\u20101 antibodies with antiphospholipid syndrome"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-8194","authenticated-orcid":false,"given":"Louis","family":"Chhor","sequence":"first","affiliation":[{"name":"Department of Rheumatology Eastern Health  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Eastern Health  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Fogarty","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Eastern Health  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Eastern Health  Box Hill Victoria Australia"},{"name":"Eastern Health Clinical School, Monash University  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8112013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001144"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-20-3328"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.80a.12171"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-004-0903-x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/096120330000900108"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0482-50042012000400013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.874741"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4237-5"},{"issue":"5","key":"e_1_2_8_11_1","first-page":"1094","article-title":"Incidence of inflammatory myopathies in Victoria, Australia, and evidence of spatial clustering","volume":"26","author":"Patrick M","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew503"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0180"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132011000100015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201800"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/CPM.0000000000000171"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0325-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.2020-8-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00163911"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133702"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00156312"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/24725625.2020.1794521"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2015.03.013"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.11.018"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu384oa"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307085251"},{"issue":"2","key":"e_1_2_8_27_1","first-page":"132","article-title":"Immunosuppressive treatment in antiphospholipid syndrome: is it worth it?","volume":"9","author":"Mormile I","year":"2021","journal-title":"Biomedicine"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2014.01.034"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.990","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.990","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T01:12:06Z","timestamp":1692839526000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,13]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/rcr2.990"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.990","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2022,6,13]]},"assertion":[{"value":"2022-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e0990"}}